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RAB8A recombinant protein :: Ras-related protein Rab-8A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717349
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ras-related protein Rab-8A (RAB8A), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Ras-related protein Rab-8A

 Product Synonym Names    Oncogene c-mel
 Product Gene Name   

RAB8A recombinant protein

[Similar Products]
 Product Synonym Gene Name    MEL; RAB8 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS717349 COA    COA PDF
 Sequence Positions    3-193aa; Partial
 Sequence    KTYDYLFKLL LIGDSGVGKT CVLFRFSEDA FNSTFISTIG IDFKIRTIEL DGKRIKLQIW DTAGQERFRT ITTAYYRGAM GIMLVYDITN EKSFDNIRNW IRNIEEHASA DVEKMILGNK CDVNDKRQVS KERGEKLALD YGIKFMETSA KANINVENAF FTLARDIKAK MDKKLEGNSP QGSNQGVKIT P
 OMIM    165040
 3D Structure    ModBase 3D Structure for P61006
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RAB8A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RAB8A recombinant protein

   The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movent, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.
 Product Categories/Family for RAB8A recombinant protein    Transport
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 SDS-PAGE of RAB8A recombinant protein    RAB8A recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for RAB8A. It may not necessarily be applicable to this product.
 NCBI GI #    16933567
 NCBI GeneID    4218
 NCBI Accession #    NP_005361.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005370.4 [Other Products]
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 UniProt Primary Accession #    P61006 [Other Products]
 UniProt Secondary Accession #    P24407; Q6FHV5; B4DEK7 [Other Products]
 UniProt Related Accession #    P61006 [Other Products]
 Molecular Weight    49.1kD
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 NCBI Official Full Name    ras-related protein Rab-8A
 NCBI Official Synonym Full Names    RAB8A, member RAS oncogene family
 NCBI Official Symbol    RAB8A [Similar Products]
 NCBI Official Synonym Symbols   
MEL; RAB8
[Similar Products]
 NCBI Protein Information    ras-related protein Rab-8A
 UniProt Protein Name    Ras-related protein Rab-8A
 UniProt Synonym Protein Names   
Oncogene c-mel
 Protein Family    Ras-related protein
 UniProt Gene Name    RAB8A [Similar Products]
 UniProt Synonym Gene Names    MEL; RAB8 [Similar Products]
 UniProt Entry Name    RAB8A_HUMAN
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 NCBI Summary for RAB8A    The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RAB8A    RAB8A: May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3. Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B. Interacts with PIFO/C1orf88. Interacts with BIRC6/bruce. Interacts with OCRL. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein, monomeric; G protein; Oncoprotein; G protein, monomeric, Rab; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: cell soma; centriole; centrosome; cilium; cytoplasmic vesicle membrane; cytosol; dendrite; Golgi membrane; nonmotile primary cilium; nucleolus; nucleus; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; postsynaptic density; recycling endosome membrane; synaptic vesicle; trans-Golgi network transport vesicle

Molecular Function: GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding; protein kinase binding; Rab GTPase binding

Biological Process: axonogenesis; cellular response to insulin stimulus; cilium biogenesis; G2/M transition of mitotic cell cycle; Golgi vesicle fusion to target membrane; mitotic cell cycle; organelle organization and biogenesis; protein secretion; regulation of long-term neuronal synaptic plasticity; regulation of protein transport; small GTPase mediated signal transduction; vesicle docking during exocytosis
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Product References and Citations for RAB8A recombinant protein

   A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells.Zahraoui A., Joberty G., Arpin M., Fontaine J.J., Hellio R., Tavitian A., Louvard D.J. Cell Biol. 124:101-115(1994)
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 Research Articles on RAB8A    1. Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RAB8A recombinant proteinPathways associated with RAB8A recombinant protein
 Reference Product  PubMed Publications
 TBC1D4 recombinant protein  >6 publications with RAB8A and TBC1D4
 OPTN recombinant protein  >5 publications with RAB8A and OPTN
 RAB1B recombinant protein  >3 publications with RAB8A and RAB1B
 OCRL recombinant protein  >2 publications with RAB8A and OCRL
 CCP110 recombinant protein  >1 publications with RAB8A and CCP110
 RAB3IP recombinant protein  >1 publications with RAB8A and RAB3IP
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
Diseases associated with RAB8A recombinant proteinOrgans/Tissues associated with RAB8A recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >14 publications with RAB8A and Nervous System Diseases
 Kidney Diseases Antibodies  >5 publications with RAB8A and Kidney Diseases
 Heart Diseases Antibodies  >2 publications with RAB8A and Heart Diseases
 Movement Disorders Antibodies  >2 publications with RAB8A and Movement Disorders
 Ataxia Antibodies  >1 publications with RAB8A and Ataxia
 Liver Diseases Antibodies  >1 publications with RAB8A and Liver Diseases
 Inflammation Antibodies  >1 publications with RAB8A and Inflammation
 Cognition Disorders Antibodies  >1 publications with RAB8A and Cognition Disorders
 Weight Loss Antibodies  >1 publications with RAB8A and Weight Loss
 Fatty Liver Antibodies  >1 publications with RAB8A and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >18 publications with RAB8A and Kidney
 Brain Antibodies  >15 publications with RAB8A and Brain
 Eye Antibodies  >13 publications with RAB8A and Eye
 Intestine Antibodies  >9 publications with RAB8A and Intestine
 Muscle Antibodies  >7 publications with RAB8A and Muscle
 Nerve Antibodies  >6 publications with RAB8A and Nerve
 Blood Antibodies  >5 publications with RAB8A and Blood
 Heart Antibodies  >3 publications with RAB8A and Heart
 Bladder Antibodies  >2 publications with RAB8A and Bladder
 Uterus Antibodies  >2 publications with RAB8A and Uterus
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