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PTPRD recombinant protein :: Receptor-type tyrosine-protein phosphatase delta (PTPRD), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950034 PTPRD recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $835 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $835 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,055 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,055 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,170 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,170 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,620 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,620 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Receptor-type tyrosine-protein phosphatase delta (PTPRD), partial, Recombinant Protein

 Also Known As   

Recombinant Human Receptor-type tyrosine-protein phosphatase delta (PTPRD), partial

 Product Synonym Names    Receptor-type tyrosine-protein phosphatase delta; Protein-tyrosine phosphatase delta; R-PTP-delta; EC=3.1.3.48
 Product Gene Name   

PTPRD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1183-1265; Provide the partial of Isoform 1 (identifier: P23468-1).
 Sequence    GREVELKPYI AAHFDVLPTE FTLGDDKHYG GFTNKQLQSG QEYVFFVLAV MEHAESKMYA TSPYSDPVVS MDLDPQPITD EEE
 OMIM    601598
 3D Structure    ModBase 3D Structure for P23468
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PTPRD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PTPRD recombinant protein

   This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported.
NCBI/Uniprot data below describe general gene information for PTPRD. It may not necessarily be applicable to this product.
 NCBI GI #    283484024
 NCBI GeneID    5789
 NCBI Accession #    NP_001164496.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001171025.1 [Other Products]
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 UniProt Primary Accession #    P23468 [Other Products]
 UniProt Secondary Accession #    Q3KPJ0; Q3KPJ1; Q3KPJ2; B1ALA0; F5GWT7 [Other Products]
 UniProt Related Accession #    P23468 [Other Products]
 Molecular Weight    169,277 Da
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 NCBI Official Full Name    receptor-type tyrosine-protein phosphatase delta isoform 6
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type, D
 NCBI Official Symbol    PTPRD [Similar Products]
 NCBI Official Synonym Symbols   
HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase delta; R-PTP-delta; protein tyrosine phosphatase, receptor type, delta polypeptide
 UniProt Protein Name    Receptor-type tyrosine-protein phosphatase delta
 Protein Family    Receptor-type tyrosine-protein phosphatase
 UniProt Gene Name    PTPRD [Similar Products]
 UniProt Synonym Gene Names    Protein-tyrosine phosphatase delta; R-PTP-delta [Similar Products]
 UniProt Entry Name    PTPRD_HUMAN
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 NCBI Summary for PTPRD    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
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 UniProt Comments for PTPRD    PTPRD: is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.1.3.48; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 9p23-p24.3

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; cell adhesion molecule binding; receptor binding

Biological Process: heterophilic cell adhesion; neuron differentiation; positive regulation of dendrite morphogenesis; protein amino acid dephosphorylation; transmembrane receptor protein tyrosine phosphatase signaling pathway; phosphate metabolic process
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 Research Articles on PTPRD    1. We reveal that PTPRD is a bona fide tumor suppressor, pinpoint PTPRD loss as a cause of aberrant STAT3 activation in gliomas, and establish PTPRD loss, in the setting of CDKN2A/p16(INK4A) deletion, as a driver of glioma progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTPRD recombinant proteinDiseases associated with PTPRD recombinant protein
 Reference Product  PubMed Publications
 SRC recombinant protein  >13 publications with PTPRD and SRC
 STAT3 recombinant protein  >10 publications with PTPRD and STAT3
 PPFIA1 recombinant protein  >7 publications with PTPRD and PPFIA1
 MTSS1 recombinant protein  >2 publications with PTPRD and MTSS1
 PPFIA2 recombinant protein  >1 publications with PTPRD and PPFIA2
 IL1RAP recombinant protein  >1 publications with PTPRD and IL1RAP
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >40 publications with PTPRD and Nervous System Diseases
 Lung Neoplasms Antibodies  >15 publications with PTPRD and Lung Neoplasms
 Brain Diseases Antibodies  >15 publications with PTPRD and Brain Diseases
 Disease Models, Animal Antibodies  >13 publications with PTPRD and Disease Models, Animal
 Colorectal Neoplasms Antibodies  >13 publications with PTPRD and Colorectal Neoplasms
 Restless Legs Syndrome Antibodies  >11 publications with PTPRD and Restless Legs Syndrome
 Breast Neoplasms Antibodies  >8 publications with PTPRD and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >6 publications with PTPRD and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >6 publications with PTPRD and Kidney Diseases
 Liver Diseases Antibodies  >5 publications with PTPRD and Liver Diseases
Organs/Tissues associated with PTPRD recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with PTPRD and Brain
 Lung Antibodies  >33 publications with PTPRD and Lung
 Eye Antibodies  >25 publications with PTPRD and Eye
 Embryonic Tissue Antibodies  >23 publications with PTPRD and Embryonic Tissue
 Muscle Antibodies  >15 publications with PTPRD and Muscle
 Bone Antibodies  >11 publications with PTPRD and Bone
 Kidney Antibodies  >10 publications with PTPRD and Kidney
 Heart Antibodies  >10 publications with PTPRD and Heart
 Skin Antibodies  >9 publications with PTPRD and Skin
 Liver Antibodies  >9 publications with PTPRD and Liver
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