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RCVRN recombinant protein :: Recoverin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS965646
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $150 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $225 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $290 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $495 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $795 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $900 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,130 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,135 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,305 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,635 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,730 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,065 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,185 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Recoverin (RCVRN), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Recoverin

 Product Synonym Names    Cancer-associated retinopathy protein; Protein CAR
 Product Gene Name   

RCVRN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS965646 COA    COA PDF
 MBS965646 MSDS    MSDS PDF
 Sequence Positions    2-200. Mature full length protein.
 Sequence    GNSKSGALSK EILEELQLNT KFSEEELCSW YQSFLKDCPT GRITQQQFQS IYAKFFPDTD PKAYAQHVFR SFDSNLDGTL DFKEYVIALH MTTAGKTNQK LEWAFSLYDV DGNGTISKNE VLEIVMAIFK MITPEDVKLL PDDENTPEKR AEKIWKYFGK NDDDKLTEKE FIEGTLANKE ILRLIQFEPQ KVKEKMKNA
 OMIM    179618
 3D Structure    ModBase 3D Structure for P35243
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RCVRN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RCVRN recombinant protein

   Ses to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.
 Product Categories/Family for RCVRN recombinant protein    Neuroscience
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 SDS-Page of RCVRN recombinant protein    RCVRN recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for RCVRN. It may not necessarily be applicable to this product.
 NCBI GI #    4506459
 NCBI GeneID    5957
 NCBI Accession #    NP_002894.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002903.2 [Other Products]
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 UniProt Primary Accession #    P35243 [Other Products]
 UniProt Secondary Accession #    Q53XL0 [Other Products]
 UniProt Related Accession #    P35243 [Other Products]
 Molecular Weight    27.1kD
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 NCBI Official Full Name    recoverin
 NCBI Official Synonym Full Names    recoverin
 NCBI Official Symbol    RCVRN [Similar Products]
 NCBI Official Synonym Symbols   
RCV1
[Similar Products]
 NCBI Protein Information    recoverin
 UniProt Protein Name    Recoverin
 UniProt Synonym Protein Names   
Cancer-associated retinopathy protein; Protein CAR
 Protein Family    Recoverin
 UniProt Gene Name    RCVRN [Similar Products]
 UniProt Synonym Gene Names    RCV1; Protein CAR [Similar Products]
 UniProt Entry Name    RECO_HUMAN
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 NCBI Summary for RCVRN    This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RCVRN    RCV1: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse. Belongs to the recoverin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 17p13.1

Molecular Function: calcium ion binding; calcium sensitive guanylate cyclase activator activity

Biological Process: phototransduction, visible light; positive regulation of guanylate cyclase activity; regulation of calcium ion transport; regulation of rhodopsin mediated signaling; rhodopsin mediated signaling; signal transduction; visual perception
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Product References and Citations for RCVRN recombinant protein

   Isolation of human retinal genes recoverin cDNA and gene.Murakami A., Yajima T., Inana G.Biochem. Biophys. Res. Commun. 187:234-244(1992) Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina.Wiechmann A.F., Hammarback J.A.Exp. Eye Res. 56:463-470(1993) The cancer-associated retinopathy antigen is a recoverin-like protein.Thirkill C.E., Tait R.C., Tyler N.K., Roth A.M., Keltner J.L.Invest. Ophthalmol. Vis. Sci. 33:2768-2772(1992) Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines.Matsubara S., Yamaji Y., Sato M., Fujita J., Takahara J.Br. J. Cancer 74:1419-1422(1996) Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy.Polans A.S., Buczylko J., Crabb J., Palczewski K.J. Cell Biol. 112:981-989(1991) Crystal structure of human recoverin at 2.2 A resolution.RIKEN structural genomics initiative (RSGI) Submitted (FEB-2007) to the PDB data bank
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 Research Articles on RCVRN    1. C39D substitution reduces alpha-helical content, decreases thermal stability and suppresses membrane association.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RCVRN recombinant proteinPathways associated with RCVRN recombinant protein
 Reference Product  PubMed Publications
 GRK1 recombinant protein  >10 publications with RCVRN and GRK1
 CALB2 recombinant protein  >5 publications with RCVRN and CALB2
 RHO recombinant protein  >3 publications with RCVRN and RHO
 Products by Pathway  Pathway Diagram
 Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway antibodies  Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Phototransduction Cascade Pathway antibodies  The Phototransduction Cascade Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
Diseases associated with RCVRN recombinant proteinOrgans/Tissues associated with RCVRN recombinant protein
 Disease Name  Pubmed Publications
 Retinal Diseases Antibodies  >85 publications with RCVRN and Retinal Diseases
 Immune System Diseases Antibodies  >20 publications with RCVRN and Immune System Diseases
 Disease Models, Animal Antibodies  >9 publications with RCVRN and Disease Models, Animal
 Uterine Neoplasms Antibodies  >6 publications with RCVRN and Uterine Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with RCVRN and Cardiovascular Diseases
 Optic Nerve Diseases Antibodies  >3 publications with RCVRN and Optic Nerve Diseases
 Inflammation Antibodies  >3 publications with RCVRN and Inflammation
 Congenital Abnormalities Antibodies  >2 publications with RCVRN and Congenital Abnormalities
 Weight Loss Antibodies  >2 publications with RCVRN and Weight Loss
 Prostatic Neoplasms Antibodies  >2 publications with RCVRN and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >196 publications with RCVRN and Eye
 Blood Antibodies  >42 publications with RCVRN and Blood
 Lung Antibodies  >37 publications with RCVRN and Lung
 Brain Antibodies  >27 publications with RCVRN and Brain
 Pineal Gland Antibodies  >6 publications with RCVRN and Pineal Gland
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