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REG1B recombinant protein :: Regenerating Islet-Derived 1 Beta Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142946 REG1B recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,170 +5 FREE 8GB USB
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 Product Name   

Regenerating Islet-Derived 1 Beta (REG1B), Recombinant Protein

 Also Known As   

Recombinant Human Regenerating Islet-Derived 1 Beta

 Product Synonym Names    REG1B Human; Regenerating Islet-Derived 1 Beta Human Recombinant; Lithostathine-1-beta; Regenerating protein I beta; REG1B; REGL
 Product Gene Name   

REG1B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    167771
 3D Structure    ModBase 3D Structure for P48304
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 20mM Tris, pH 8.0.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of REG1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for REG1B recombinant protein

   Description: The Recombinant Human REG 1 beta manufactured with N-terminal fusion of His Tag. The Human REG 1 beta His-Tagged Fusion Protein, produced in E Coli, is 17.8 kDa protein containing 144 amino acid residues of the Human REG 1 beta and 12 additional amino acid residues His Tag (underlined).

Introduction: Reg protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggests that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA which encodes a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein.Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta. In patients with chronic hypergastrinemia, Reg production is stimulated, with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa, partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls, and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholithiasis, and various cancers of the digestive system.
 Product Categories/Family for REG1B recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Regenerating Islet-Derived
NCBI/Uniprot data below describe general gene information for REG1B. It may not necessarily be applicable to this product.
 NCBI GI #    10835248
 NCBI GeneID    5968
 NCBI Accession #    NP_006498.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006507.3 [Other Products]
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 UniProt Primary Accession #    P48304 [Other Products]
 UniProt Related Accession #    P48304 [Other Products]
 Molecular Weight    18,665 Da
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 NCBI Official Full Name    lithostathine-1-beta
 NCBI Official Synonym Full Names    regenerating islet-derived 1 beta
 NCBI Official Symbol    REG1B [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    lithostathine-1-beta; PSP-2; REG-1-beta; lithostathine 1 beta; pancreatic stone protein 2; regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein); regenerating islet-derived protein 1-beta; regenerating protein I beta; secretory pancreatic stone protein 2
 UniProt Protein Name    Lithostathine-1-beta
 UniProt Synonym Protein Names   
Pancreatic stone protein 2; PSP-2; Regenerating islet-derived protein 1-beta; REG-1-beta; Regenerating protein I beta
 Protein Family    Lithostathine
 UniProt Gene Name    REG1B [Similar Products]
 UniProt Synonym Gene Names    PSPS2; REGL; PSP-2; REG-1-beta [Similar Products]
 UniProt Entry Name    REG1B_HUMAN
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 NCBI Summary for REG1B    This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]
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 UniProt Comments for REG1B    REG1B: Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p12

Molecular Function: carbohydrate binding

Biological Process: cell proliferation
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 Research Articles on REG1B    1. Additional serum biomarkers, particularly SYCN and REG1B, when combined with CA19.9, show promise as improved diagnostic indicators of pancreatic cancer, which therefore warrants further validation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with REG1B recombinant proteinDiseases associated with REG1B recombinant protein
 Reference Product  PubMed Publications
 REG1A recombinant protein  >16 publications with REG1B and REG1A
 Disease Name  Pubmed Publications
 Endocrine Gland Neoplasms Antibodies  >2 publications with REG1B and Endocrine Gland Neoplasms
 Pancreatic Neoplasms Antibodies  >2 publications with REG1B and Pancreatic Neoplasms
 Carcinoma, Papillary Antibodies  >1 publications with REG1B and Carcinoma, Papillary
 Necrosis Antibodies  >1 publications with REG1B and Necrosis
 Carcinoma Antibodies  >1 publications with REG1B and Carcinoma
 Asthma Antibodies  >1 publications with REG1B and Asthma
Organs/Tissues associated with REG1B recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >9 publications with REG1B and Pancreas
 Intestine Antibodies  >4 publications with REG1B and Intestine
 Stomach Antibodies  >1 publications with REG1B and Stomach
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