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REG3A recombinant protein :: Regenerating Islet-Derived 3 Alpha Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142975 REG3A recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,140 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Regenerating Islet-Derived 3 Alpha (REG3A), Recombinant Protein

 Also Known As   

Recombinant Human Regenerating Islet-Derived 3 Alpha

 Product Synonym Names    REG3A Human; Regenerating Islet-Derived 3 Alpha Human Recombinant; Regenerating islet-derived protein 3 alpha; Reg III-alpha; Pancreatitis-associated protein 1; REG3A; HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; REG-III
 Product Gene Name   

REG3A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    167805
 3D Structure    ModBase 3D Structure for Q06141
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to add 0.1M Acetate buffer pH-4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of REG3A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for REG3A recombinant protein

   Description: The Recombinant Human REG3A protein is produced with N-terminal fusion of His Tag. The REG3A His -Tagged Fusion Protein is an 18.4 kDa protein containing 149 amino acid residues of the Human REG3A and 16 additional amino acid residues- His Tag (underlined).

Introduction: Pancreatitis-associated protein (PAP) is a secretory protein not normally expressed in healthy pancreas but highly induced during acute pancreatitis. While PAP has been shown to be anti-bacterial and antiapoptotic in vitro, its definitive biological function in vivo is not clear. Using antisepse oligonucleotides, inhibition of PAP expression significantly worsened pancreatitis in a rat model. During pancreatitis, PAP released by the pancreas could mediate lung inflammation through induction of hepatic TNF- alpha expression and subsequent increase in circulating TNF-alpha.PAP is activated in primary liver cancers. In normal liver, the protein is undetectable in normal mature hepatocytes and found only in some ductular cells, representing potential hepatic progenitor cells. PAP can be considered hepatic cytokine that combines mitogenic and anti-apoptotic functions regarding hepatocytes, and consequently acts as a growth factor in vivo to enhance liver regeneration. In pancreatic cancor, PAP was overexpressed in 79% (30 of 38) of pancreatic ductal adenocarcinoma, 19% (7 of 36) of chronic pancreatitis, and 29% (2 of 7) of mucinous cystadenoma. PAP was found in malignant ductular structures in pancreatic carcinomas as well as in benign proliferating ductules and acinar cells in chronic pancreatitis. Elevation of PAP in patients with pancreatic cancer is not merely explainable by concomitant pancreatitis, but seems to be due to increased PAP production by the cancer cells and is also correlated to tumour load as expressed by the UICC stages.Epithelial expression of PAP was induced under intestinal mucosal inflammation initiated by exposure to commensal bacteria or DSS as well as inflamed IBD colon. Increased serum level of PAP diagnosed ileal location in active Crohn disease with a sensitivity of 60%, a specificity of 94%, a positive predictive value of 84% and a negative predictive value of 81%. Elevated serum PAP (> 50 ng/mL) is significantly associated with disease activity and ileal location of Crohn disease.
 Product Categories/Family for REG3A recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Regenerating Islet-Derived
 Applications Tested/Suitable for REG3A recombinant protein   

Western Blot (WB), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for REG3A. It may not necessarily be applicable to this product.
 NCBI GI #    4505605
 NCBI GeneID    5068
 NCBI Accession #    NP_002571.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002580.2 [Other Products]
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 UniProt Primary Accession #    Q06141 [Other Products]
 UniProt Related Accession #    Q06141 [Other Products]
 Molecular Weight    19,395 Da
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 NCBI Official Full Name    regenerating islet-derived protein 3-alpha
 NCBI Official Synonym Full Names    regenerating islet-derived 3 alpha
 NCBI Official Symbol    REG3A [Similar Products]
 NCBI Official Synonym Symbols   
HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
[Similar Products]
 NCBI Protein Information    regenerating islet-derived protein 3-alpha; PAP homologous protein; REG-3-alpha; hepatocarcinoma-intestine-pancreas; hepatointestinal pancreatic protein; human proislet peptide; pancreatic beta cell growth factor; pancreatitis-associated protein 1; proliferation-inducing protein 34; proliferation-inducing protein 42; reg III-alpha; regenerating islet-derived protein III-alpha
 UniProt Protein Name    Regenerating islet-derived protein 3-alpha
 UniProt Synonym Protein Names   
Hepatointestinal pancreatic protein; HIP/PAP; Human proislet peptide; Pancreatitis-associated protein 1; Regenerating islet-derived protein III-alpha; Reg III-alpha
 Protein Family    Regenerating islet-derived protein
 UniProt Gene Name    REG3A [Similar Products]
 UniProt Synonym Gene Names    HIP; PAP; PAP1; REG-3-alpha; HIP/PAP; Reg III-alpha [Similar Products]
 UniProt Entry Name    REG3A_HUMAN
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 NCBI Summary for REG3A    This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
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 UniProt Comments for REG3A    REG3A: Might be a stress protein involved in the control of bacterial proliferation.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: extracellular space; cytoplasm

Molecular Function: carbohydrate binding

Biological Process: heterophilic cell adhesion; cell proliferation; multicellular organismal development; negative regulation of keratinocyte differentiation; acute-phase response
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 Research Articles on REG3A    1. Serum regenerating islet-derived 3-alpha is a biomarker of mucosal enteropathies
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Recombinant Human Regenerating Islet-Derived 3 Alpha
 Catalog #  Product Name  Catalog #  Product Name
 MBS916893  Mouse Regenerating islet-derived protein 3-alpha, REG3A ELISA Kit  MBS928967  Rat Regenerating islet-derived protein 3-alpha, REG3A ELISA Kit
 MBS141016  Polyclonal Rabbit Anti Human Regenerating Islet-Derived 3 Alpha  MBS142975  Recombinant Human Regenerating Islet-Derived 3 Alpha
 MBS937542  Human Regenerating islet-derived protein 3-alpha, REG3A ELISA Kit
Products associated with REG3A recombinant proteinDiseases associated with REG3A recombinant protein
 Reference Product  PubMed Publications
 REG1A recombinant protein  >6 publications with REG3A and REG1A
 FN1 recombinant protein  >1 publications with REG3A and FN1
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >7 publications with REG3A and Carcinoma
 Inflammation Antibodies  >7 publications with REG3A and Inflammation
 Adenocarcinoma Antibodies  >5 publications with REG3A and Adenocarcinoma
 Pancreatic Neoplasms Antibodies  >3 publications with REG3A and Pancreatic Neoplasms
 Liver Neoplasms Antibodies  >3 publications with REG3A and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with REG3A and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >2 publications with REG3A and Disease Models, Animal
 Liver Cirrhosis Antibodies  >2 publications with REG3A and Liver Cirrhosis
 Insulin Resistance Antibodies  >1 publications with REG3A and Insulin Resistance
 Colonic Neoplasms Antibodies  >1 publications with REG3A and Colonic Neoplasms
Organs/Tissues associated with REG3A recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >11 publications with REG3A and Pancreas
 Liver Antibodies  >5 publications with REG3A and Liver
 Intestine Antibodies  >5 publications with REG3A and Intestine
 Stomach Antibodies  >2 publications with REG3A and Stomach
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