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REG4 recombinant protein :: Regenerating Islet-Derived 4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142978 REG4 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,170 +5 FREE 8GB USB
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 Product Name   

Regenerating Islet-Derived 4 (REG4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Regenerating Islet-Derived 4

 Product Synonym Names    REG4 Human; Regenerating Islet-Derived 4 Human Recombinant; Regenerating islet-derived protein 4; Reg IV; REG-like protein; Gastrointestinal secretory protein; REG4; GISP; RELP
 Product Gene Name   

REG4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609846
 3D Structure    ModBase 3D Structure for Q9BYZ8
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 20mM Tris, pH 8.0.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of REG4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for REG4 recombinant protein

   Description: The Recombinant Human REG-4 is manufactured with N-terminal fusion of His Tag. The Recombinant Human REG-IV His-Tagged Fusion Protein is 17.4 kDa protein containing 136 amino acid residues of the Human REG 4 and 12 additional amino acid residues His Tag (underlined).

Introduction: REG protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggests that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA which encodes a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein.Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta. In patients with chronic hypergastrinemia, Reg production is stimulated, with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa, partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls, and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholithiasis, and various cancers of the digestive system.
 Product Categories/Family for REG4 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Regenerating Islet-Derived
NCBI/Uniprot data below describe general gene information for REG4. It may not necessarily be applicable to this product.
 NCBI GI #    226823233
 NCBI GeneID    83998
 NCBI Accession #    NP_001152824.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001159352.1 [Other Products]
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 UniProt Primary Accession #    Q9BYZ8 [Other Products]
 UniProt Secondary Accession #    Q8NER6; Q8NER7 [Other Products]
 UniProt Related Accession #    Q9BYZ8 [Other Products]
 Molecular Weight    14,993 Da
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 NCBI Official Full Name    regenerating islet-derived protein 4 isoform 1
 NCBI Official Synonym Full Names    regenerating islet-derived family, member 4
 NCBI Official Symbol    REG4 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    regenerating islet-derived protein 4; REG-4; REG-like protein; gastrointestinal secretory protein; reg IV; regenerating gene type IV; regenerating islet-derived protein IV
 UniProt Protein Name    Regenerating islet-derived protein 4
 UniProt Synonym Protein Names   
Gastrointestinal secretory protein; REG-like protein; Regenerating islet-derived protein IV; Reg IV
 Protein Family    Regenerating islet-derived protein
 UniProt Gene Name    REG4 [Similar Products]
 UniProt Synonym Gene Names    GISP; RELP; REG-4; Reg IV [Similar Products]
 UniProt Entry Name    REG4_HUMAN
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 UniProt Comments for REG4    REG4: Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p13.1-p12

Cellular Component: cytoplasm; extracellular region

Molecular Function: heparin binding; calcium ion binding
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 Research Articles on REG4    1. miR-24 functions as a novel tumor suppressor in gastric cancer, and the anti-oncogenic activity may involve its inhibition of the target gene REG4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with REG4 recombinant proteinOrgans/Tissues associated with REG4 recombinant protein
 Disease Name  Pubmed Publications
 Gastrointestinal Diseases Antibodies  >56 publications with REG4 and Gastrointestinal Diseases
 Carcinoma Antibodies  >33 publications with REG4 and Carcinoma
 Colorectal Neoplasms Antibodies  >28 publications with REG4 and Colorectal Neoplasms
 Stomach Neoplasms Antibodies  >22 publications with REG4 and Stomach Neoplasms
 Neoplasm Metastasis Antibodies  >10 publications with REG4 and Neoplasm Metastasis
 Colonic Neoplasms Antibodies  >8 publications with REG4 and Colonic Neoplasms
 Colitis Antibodies  >6 publications with REG4 and Colitis
 Liver Neoplasms Antibodies  >4 publications with REG4 and Liver Neoplasms
 Inflammation Antibodies  >4 publications with REG4 and Inflammation
 Prostatic Neoplasms Antibodies  >4 publications with REG4 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >25 publications with REG4 and Stomach
 Intestine Antibodies  >20 publications with REG4 and Intestine
 Pancreas Antibodies  >10 publications with REG4 and Pancreas
 Prostate Antibodies  >5 publications with REG4 and Prostate
 Lung Antibodies  >3 publications with REG4 and Lung
 Mammary Gland Antibodies  >1 publications with REG4 and Mammary Gland
 Ovary Antibodies  >1 publications with REG4 and Ovary
 Ascites Antibodies  >1 publications with REG4 and Ascites
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