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RLN recombinant protein :: Relaxin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031146 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $150 +1 FREE 8GB USB
0.05 mg  /  $285 +1 FREE 8GB USB
0.1 mg  /  $445 +1 FREE 8GB USB
0.2 mg  /  $550 +1 FREE 8GB USB
0.5 mg  /  $1,060 +1 FREE 8GB USB
1 mg  /  $1,580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Relaxin (RLN), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Relaxin (RLN)

 Product Gene Name   

RLN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    179730
 3D Structure    ModBase 3D Structure for P04808
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 Host    E Coli
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 Purity/Purification    >95%
 Form/Format    100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
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 Source    Prokaryotic expression.
 Residues    Arg23~Cys186
 Tags    N-terminal His-Tag
 Tissue Specificity    Prostate.
 Subcellular Location    Secreted.
 Traits    Freeze-dried powder
 Predicted isoelectric point    9.1
 Predicted Molecular Mass    23.7kDa
 Accurate Molecular Mass    20kDa as determined by SDS-PAGE reducing conditions.
 Phenomenon explanation    The possible reasons that the actual band size differs from the predicted are as follows:
1. Splice variants: Alternative splicing may create different sized proteins from the same gene.
2. Relative charge: The composition of amino acids may affects the charge of the protein.
3.Post-translational modification: Phosphorylation, glycosylation, methylation etc.
4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
5. Polymerization of the target protein: Dimerization, multimerization etc.
 Usage    Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of RLN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for RLN recombinant protein   

SDS-PAGE, WB, ELISA, IP, CoIP, ReporterAssays, Purification, Amine Reactive Labeling.
(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of RLN recombinant protein    RLN recombinant protein Sequence image
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 Sequence ID of RLN recombinant protein    RLN recombinant protein Sequence ID image
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 SDS-Page of RLN recombinant protein    RLN recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for RLN. It may not necessarily be applicable to this product.
 NCBI GI #    35923
 NCBI GeneID    6013
 NCBI Accession #    CAA23838.1 [Other Products]
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 UniProt Primary Accession #    P04808 [Other Products]
 UniProt Secondary Accession #    Q99936; Q9UQJ1 [Other Products]
 UniProt Related Accession #    P04808 [Other Products]
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 NCBI Official Full Name    relaxin, partial
 NCBI Official Synonym Full Names    relaxin 1
 NCBI Official Symbol    RLN1 [Similar Products]
 NCBI Official Synonym Symbols   
H1; H1RLX; RLXH1; bA12D24.3.1; bA12D24.3.2
[Similar Products]
 NCBI Protein Information    prorelaxin H1
 UniProt Protein Name    Prorelaxin H1
 Protein Family    Relaxin
 UniProt Gene Name    RLN1 [Similar Products]
 UniProt Entry Name    REL1_HUMAN
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 NCBI Summary for RLN    Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
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 UniProt Comments for RLN    RLN1: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular region

Molecular Function: hormone activity

Biological Process: female pregnancy; signal transduction
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 Research Articles on RLN    1. Rln enhanced synergistically BMP-2-induced osteoblast differentiation and bone formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RLN recombinant proteinPathways associated with RLN recombinant protein
 Reference Product  PubMed Publications
 RXFP1 recombinant protein  >8 publications with RLN and RXFP1
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
Diseases associated with RLN recombinant proteinOrgans/Tissues associated with RLN recombinant protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >10 publications with RLN and Fibrosis
 Heart Diseases Antibodies  >5 publications with RLN and Heart Diseases
 Premature Birth Antibodies  >3 publications with RLN and Premature Birth
 Genital Diseases, Male Antibodies  >3 publications with RLN and Genital Diseases, Male
 Death Antibodies  >3 publications with RLN and Death
 Lung Diseases Antibodies  >3 publications with RLN and Lung Diseases
 Disease Models, Animal Antibodies  >3 publications with RLN and Disease Models, Animal
 Hypertrophy Antibodies  >3 publications with RLN and Hypertrophy
 Body Weight Changes Antibodies  >2 publications with RLN and Body Weight Changes
 Prostatic Neoplasms Antibodies  >2 publications with RLN and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with RLN and Brain
 Blood Antibodies  >7 publications with RLN and Blood
 Prostate Antibodies  >6 publications with RLN and Prostate
 Connective Tissue Antibodies  >5 publications with RLN and Connective Tissue
 Testis Antibodies  >2 publications with RLN and Testis
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