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RETN recombinant protein :: Resistin Mutant Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143340 RETN recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $6,380 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Resistin Mutant (RETN), Recombinant Protein

 Also Known As   

Recombinant Human Resistin Mutant

 Product Synonym Names    Resistin Mutant Human; Resistin Mutant Human Recombinant; Resistin; Cysteine-rich secreted protein FIZZ3; Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; RSTN; XCP1; RETN1; MGC126603; MGC126609; Resistin Mutant
 Product Gene Name   

RETN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSSKTLCSME EAINERIQEV AGSLIFRAIS SIGLECQSVT SRGDLATCPR GFAVTGCTCG SACGSWDVRA ETTCHCQCAG MDWTGARCCR VQP.
 OMIM    605565
 3D Structure    ModBase 3D Structure for Q9HD89
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    Recombinant Human Resistin was lyophilized from a concentrated (1mg/ml) solution containing 0.1% TFA.
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 Solubility    Add 0.2 ml of deionized water and let the lyophilized pellet dissolve completely.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
 Other Notes    Small volumes of RETN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for RETN recombinant protein

   Description: 9.9 kDa protein containing 93 amino acid residues, produced in E Coli. Mutant-Resistin has had a Cysteine residue mutated to prevent dimerization and possibly acts as an antagonist.

Introduction: Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which is termed the RELM family, and is also described as ADSF (Adipose Tissue- Specific Secretory Factor) and FIZZ3 (Found in Inflammatory Zone). Human resistin contains 108 amino acids as a prepeptide, and its hydrophobic signal peptide is cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26.Resistin may be an important link between obesity and insulin resistance. Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin. Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulate glucose uptake. They have also suggested that resistin is present at elevated levels in blood of obese mice, and is down regulated by fasting and antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severely suppressed in obesity and is stimulated by several antidiabetic drugs.Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression.
 Product Categories/Family for RETN recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Resistin
NCBI/Uniprot data below describe general gene information for RETN. It may not necessarily be applicable to this product.
 NCBI GI #    301129180
 NCBI GeneID    56729
 NCBI Accession #    NP_001180303.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001193374.1 [Other Products]
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 UniProt Primary Accession #    Q9HD89 [Other Products]
 UniProt Secondary Accession #    Q540D9; Q76B53; D6W649 [Other Products]
 UniProt Related Accession #    Q9HD89 [Other Products]
 Molecular Weight    8,686 Da [Similar Products]
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 NCBI Official Full Name    resistin
 NCBI Official Synonym Full Names    resistin
 NCBI Official Symbol    RETN [Similar Products]
 NCBI Official Synonym Symbols   
ADSF; RSTN; XCP1; FIZZ3; RETN1
[Similar Products]
 NCBI Protein Information    resistin; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1; adipose tissue-specific secretory factor; c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; cysteine-rich secreted protein A12-alpha-like 2; cysteine-rich secreted protein FIZZ3; found in inflammatory zone 3; resistin delta2
 UniProt Protein Name    Resistin
 UniProt Synonym Protein Names   
Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3
 Protein Family    Resistin
 UniProt Gene Name    RETN [Similar Products]
 UniProt Synonym Gene Names    FIZZ3; HXCP1; RSTN; ADSF [Similar Products]
 UniProt Entry Name    RETN_HUMAN
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 NCBI Summary for RETN    This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for RETN    resistin: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Belongs to the resistin/FIZZ family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular space; nucleus

Molecular Function: hormone activity

Biological Process: fat cell differentiation; response to mechanical stimulus; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell migration; positive regulation of synaptic transmission; aging; response to insulin stimulus

Disease: Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on RETN    1. These results provide new evidence that resistin may contribute to the vascular lesion formation via increasing endothelial permeability through the mechanism of oxidative stress and the activation of p38 MAPK.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RETN recombinant proteinPathways associated with RETN recombinant protein
 Reference Product  PubMed Publications
 LEP recombinant protein  >9 publications with RETN and LEP
 SOCS3 recombinant protein  >6 publications with RETN and SOCS3
 GHRL recombinant protein  >5 publications with RETN and GHRL
 CD36 recombinant protein  >4 publications with RETN and CD36
 NPY recombinant protein  >3 publications with RETN and NPY
 AKT1 recombinant protein  >2 publications with RETN and AKT1
 INSR recombinant protein  >2 publications with RETN and INSR
 INS recombinant protein  >2 publications with RETN and INS
 IGF1 recombinant protein  >1 publications with RETN and IGF1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
Diseases associated with RETN recombinant proteinOrgans/Tissues associated with RETN recombinant protein
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >339 publications with RETN and Insulin Resistance
 Inflammation Antibodies  >118 publications with RETN and Inflammation
 Cardiovascular Diseases Antibodies  >111 publications with RETN and Cardiovascular Diseases
 Diabetes Mellitus, Type 2 Antibodies  >106 publications with RETN and Diabetes Mellitus, Type 2
 Necrosis Antibodies  >102 publications with RETN and Necrosis
 Atherosclerosis Antibodies  >60 publications with RETN and Atherosclerosis
 Hypertension Antibodies  >36 publications with RETN and Hypertension
 Metabolic Syndrome X Antibodies  >33 publications with RETN and Metabolic Syndrome X
 Coronary Disease Antibodies  >30 publications with RETN and Coronary Disease
 Heart Diseases Antibodies  >30 publications with RETN and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >390 publications with RETN and Blood
 Intestine Antibodies  >10 publications with RETN and Intestine
 Placenta Antibodies  >8 publications with RETN and Placenta
 Bone Marrow Antibodies  >5 publications with RETN and Bone Marrow
 Eye Antibodies  >2 publications with RETN and Eye
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