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ABCA4 recombinant protein :: Retinal-specific ATP-binding cassette transporter (ABCA4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS952504 ABCA4 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Retinal-specific ATP-binding cassette transporter (ABCA4), Recombinant Protein

 Also Known As   

Recombinant Human Retinal-specific ATP-binding cassette transporter (ABCA4) , partial

 Product Gene Name   

ABCA4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    153800
 3D Structure    ModBase 3D Structure for P78363
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABCA4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ABCA4. It may not necessarily be applicable to this product.
 NCBI GI #    105990541
 NCBI GeneID    24
 NCBI Accession #    NP_000341.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000350.2 [Other Products]
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 UniProt Primary Accession #    P78363 [Other Products]
 UniProt Secondary Accession #    O15112; O60438; O60915; Q0QD48; Q4LE31 [Other Products]
 UniProt Related Accession #    P78363 [Other Products]
 Molecular Weight    255,944 Da
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 NCBI Official Full Name    retinal-specific ATP-binding cassette transporter
 NCBI Official Synonym Full Names    ATP binding cassette subfamily A member 4
 NCBI Official Symbol    ABCA4 [Similar Products]
 NCBI Official Synonym Symbols   
FFM; RMP; ABCR; RP19; STGD; ABC10; ARMD2; CORD3; STGD1
[Similar Products]
 NCBI Protein Information    retinal-specific ATP-binding cassette transporter
 UniProt Protein Name    Retinal-specific ATP-binding cassette transporter
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Stargardt disease protein
 Protein Family    Retinal-specific ATP-binding cassette transporter
 UniProt Gene Name    ABCA4 [Similar Products]
 UniProt Synonym Gene Names    ABCR; RIM protein; RmP [Similar Products]
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 NCBI Summary for ABCA4    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCA4    In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.
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 Research Articles on ABCA4    1. Studies indicate that variants in ABCA4 are associated with a wide variety of inherited retinal diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ABCA4 recombinant proteinPathways associated with ABCA4 recombinant protein
 Reference Product  PubMed Publications
 RDH8 recombinant protein  >28 publications with ABCA4 and RDH8
 RPE65 recombinant protein  >15 publications with ABCA4 and RPE65
 ELOVL4 recombinant protein  >12 publications with ABCA4 and ELOVL4
 RDH12 recombinant protein  >11 publications with ABCA4 and RDH12
 CNGB1 recombinant protein  >4 publications with ABCA4 and CNGB1
 ROM1 recombinant protein  >4 publications with ABCA4 and ROM1
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
Diseases associated with ABCA4 recombinant proteinOrgans/Tissues associated with ABCA4 recombinant protein
 Disease Name  Pubmed Publications
 Macular Degeneration Antibodies  >302 publications with ABCA4 and Macular Degeneration
 Retinitis Pigmentosa Antibodies  >103 publications with ABCA4 and Retinitis Pigmentosa
 Stargardt disease 1 Antibodies  >93 publications with ABCA4 and Stargardt disease 1
 Disease Models, Animal Antibodies  >36 publications with ABCA4 and Disease Models, Animal
 Cone-Rod Dystrophy 3 Antibodies  >36 publications with ABCA4 and Cone-Rod Dystrophy 3
 Cleft Lip Antibodies  >14 publications with ABCA4 and Cleft Lip
 Inflammation Antibodies  >9 publications with ABCA4 and Inflammation
 Kidney Diseases Antibodies  >3 publications with ABCA4 and Kidney Diseases
 Liver Diseases Antibodies  >3 publications with ABCA4 and Liver Diseases
 Necrosis Antibodies  >2 publications with ABCA4 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >350 publications with ABCA4 and Eye
 Brain Antibodies  >22 publications with ABCA4 and Brain
 Vascular Antibodies  >10 publications with ABCA4 and Vascular
 Kidney Antibodies  >6 publications with ABCA4 and Kidney
 Bone Antibodies  >5 publications with ABCA4 and Bone
 Lung Antibodies  >4 publications with ABCA4 and Lung
 Muscle Antibodies  >4 publications with ABCA4 and Muscle
 Pancreas Antibodies  >3 publications with ABCA4 and Pancreas
 Ovary Antibodies  >2 publications with ABCA4 and Ovary
 Embryonic Tissue Antibodies  >2 publications with ABCA4 and Embryonic Tissue
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