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RBL1 recombinant protein :: Retinoblastoma-like protein 1 (RBL1), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS966479 RBL1 recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Retinoblastoma-like protein 1 (RBL1), partial, Recombinant Protein

 Also Known As   

Recombinant Human Retinoblastoma-like protein 1 (RBL1), partial

 Product Synonym Names    Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1
 Product Gene Name   

RBL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116957
 3D Structure    ModBase 3D Structure for P28749
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RBL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for RBL1 recombinant protein

   This protein is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that This protein may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for RBL1. It may not necessarily be applicable to this product.
 NCBI GI #    34577079
 NCBI GeneID    5933
 NCBI Accession #    NP_002886.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002895.3 [Other Products]
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 UniProt Primary Accession #    P28749 [Other Products]
 UniProt Secondary Accession #    Q4VXA0; Q8N5K6; Q9H1L5; Q9H1M1; A8K2W5 [Other Products]
 UniProt Related Accession #    P28749 [Other Products]
 Molecular Weight    114,688 Da
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 NCBI Official Full Name    retinoblastoma-like protein 1 isoform a
 NCBI Official Synonym Full Names    retinoblastoma-like 1
 NCBI Official Symbol    RBL1 [Similar Products]
 NCBI Official Synonym Symbols   
PRB1; p107; CP107
[Similar Products]
 NCBI Protein Information    retinoblastoma-like protein 1; cellular protein 107; retinoblastoma-like 1 (p107); 107 kDa retinoblastoma-associated protein
 UniProt Protein Name    Retinoblastoma-like protein 1
 UniProt Synonym Protein Names   
107 kDa retinoblastoma-associated protein; p107; pRb1
 Protein Family    RHOMBOID-like protein
 UniProt Gene Name    RBL1 [Similar Products]
 UniProt Synonym Gene Names    p107 [Similar Products]
 UniProt Entry Name    RBL1_HUMAN
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 NCBI Summary for RBL1    The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RBL1    Rb-like 1: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: protein binding; transcription factor binding

Biological Process: transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction; regulation of cell cycle; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression; mitotic cell cycle; regulation of lipid kinase activity; negative regulation of transcription from RNA polymerase II promoter; chromatin modification
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 Research Articles on RBL1    1. Sequence analysis of the RB1 gene detected a novel mutation in bilateral retinoblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RBL1 recombinant proteinPathways associated with RBL1 recombinant protein
 Reference Product  PubMed Publications
 RBL2 recombinant protein  >171 publications with RBL1 and RBL2
 CDK2 recombinant protein  >53 publications with RBL1 and CDK2
 E2F4 recombinant protein  >41 publications with RBL1 and E2F4
 E2F1 recombinant protein  >38 publications with RBL1 and E2F1
 CCND1 recombinant protein  >28 publications with RBL1 and CCND1
 RB1 recombinant protein  >26 publications with RBL1 and RB1
 CDK4 recombinant protein  >25 publications with RBL1 and CDK4
 MYC recombinant protein  >21 publications with RBL1 and MYC
 MYBL2 recombinant protein  >12 publications with RBL1 and MYBL2
 E2F5 recombinant protein  >9 publications with RBL1 and E2F5
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cyclin D Associated Events In G1 Pathway antibodies  Cyclin D Associated Events In G1 Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 G0 And Early G1 Pathway antibodies  G0 And Early G1 Pathway Diagram
 G1 Phase Pathway antibodies  G1 Phase Pathway Diagram
Diseases associated with RBL1 recombinant proteinOrgans/Tissues associated with RBL1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >100 publications with RBL1 and Neoplasms
 Neoplasms, Experimental Antibodies  >10 publications with RBL1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >8 publications with RBL1 and Disease Models, Animal
 Hyperplasia Antibodies  >7 publications with RBL1 and Hyperplasia
 Uterine Cervical Neoplasms Antibodies  >7 publications with RBL1 and Uterine Cervical Neoplasms
 Nervous System Diseases Antibodies  >6 publications with RBL1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >5 publications with RBL1 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >4 publications with RBL1 and Neoplasm Metastasis
 Skin Neoplasms Antibodies  >3 publications with RBL1 and Skin Neoplasms
 Liver Neoplasms Antibodies  >3 publications with RBL1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with RBL1 and Blood
 Embryonic Tissue Antibodies  >15 publications with RBL1 and Embryonic Tissue
 Liver Antibodies  >15 publications with RBL1 and Liver
 Eye Antibodies  >11 publications with RBL1 and Eye
 Lung Antibodies  >10 publications with RBL1 and Lung
 Brain Antibodies  >9 publications with RBL1 and Brain
 Skin Antibodies  >7 publications with RBL1 and Skin
 Prostate Antibodies  >6 publications with RBL1 and Prostate
 Heart Antibodies  >4 publications with RBL1 and Heart
 Uterus Antibodies  >4 publications with RBL1 and Uterus
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