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RBP4 recombinant protein :: Retinol Binding Protein-4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143193 RBP4 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Retinol Binding Protein-4 (RBP4), Recombinant Protein

 Also Known As   

Recombinant Human Retinol Binding Protein-4

 Product Synonym Names    RBP4 Human; Retinol Binding Protein-4 Human Recombinant; Retinol Binding Protein 4; RBP-4; RBP4; Plasma retinol-binding protein; PRBP; RBP
 Product Gene Name   

RBP4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MERDCRVSSF RVKENFDKAR FSGTWYAMAK KDPEGLFLQD NIVAEFSVDE TGQMSATAKG RVRLLNNWDV CADMVGTFTD TEDPAKFKMK YWGVASFLQK GNDDHWIVDT DYDTYAVQYS CRLLNLDGTC ADSYSFVFSR DPNGLPPEAQ KIVRQRQEEL CLARQYRLIV HNGYCDGRSE RNLL
 OMIM    180250
 3D Structure    ModBase 3D Structure for P02753
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    1 mg/ml in PBS pH-7.4.
Sterile Filtered colorless solution.
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 Other Notes    Small volumes of RBP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RBP4 recombinant protein

   Description: RBP-4 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (19-201 a.a.) containing 184 amino acids and having a molecular mass of 21 kDa.The Retinol Binding Protein-4 is purified by proprietary chromatographic techniques.

Introduction: Retinol binding protein 4(RBP4) belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. This protein was found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli.RBP4 delivers retinol from the liver to the peripheral tissues. In plasma, the rbp-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
 Product Categories/Family for RBP4 recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Retinol Binding Protein
NCBI/Uniprot data below describe general gene information for RBP4. It may not necessarily be applicable to this product.
 NCBI GI #    55743122
 NCBI GeneID    5950
 NCBI Accession #    NP_006735.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006744.3 [Other Products]
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 UniProt Primary Accession #    P02753 [Other Products]
 UniProt Secondary Accession #    O43478; O43479; Q5VY24; Q8WWA3; Q9P178; D3DR38 [Other Products]
 UniProt Related Accession #    P02753 [Other Products]
 Molecular Weight    23,010 Da
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 NCBI Official Full Name    retinol-binding protein 4
 NCBI Official Synonym Full Names    retinol binding protein 4, plasma
 NCBI Official Symbol    RBP4 [Similar Products]
 NCBI Official Synonym Symbols   
RDCCAS
[Similar Products]
 NCBI Protein Information    retinol-binding protein 4; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial
 UniProt Protein Name    Retinol-binding protein 4
 UniProt Synonym Protein Names   
Plasma retinol-binding protein; PRBP; RBP
 Protein Family    Retinol-binding protein
 UniProt Gene Name    RBP4 [Similar Products]
 UniProt Synonym Gene Names    PRBP; RBP [Similar Products]
 UniProt Entry Name    RET4_HUMAN
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 NCBI Summary for RBP4    This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RBP4    RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: extracellular space; protein complex; extracellular region; cytosol

Molecular Function: protein binding; protein heterodimerization activity; retinal binding; retinol binding

Biological Process: phototransduction, visible light; retinal metabolic process; embryonic skeletal development; heart development; maintenance of gastrointestinal epithelium; glucose homeostasis; uterus development; response to insulin stimulus; embryonic organ morphogenesis; retinol metabolic process; negative regulation of cardiac muscle cell proliferation; detection of light stimulus involved in visual perception; retinoid metabolic process; female genitalia morphogenesis; cardiac muscle development; response to retinoic acid; urinary bladder development; male gonad development; positive regulation of insulin secretion; vagina development; positive regulation of immunoglobulin secretion; gluconeogenesis; response to ethanol; eye development; embryonic retina morphogenesis in camera-type eye; spermatogenesis; lung development

Disease: Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome; Microphthalmia, Isolated, With Coloboma 10
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 Research Articles on RBP4    1. Two RBP4 SNPs showed associations with insulin resistance and insulin levels in women with prior gestational diabetes mellitus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RBP4 recombinant proteinPathways associated with RBP4 recombinant protein
 Reference Product  PubMed Publications
 TTR recombinant protein  >34 publications with RBP4 and TTR
 STRA6 recombinant protein  >18 publications with RBP4 and STRA6
 RETN recombinant protein  >8 publications with RBP4 and RETN
 AHSG recombinant protein  >5 publications with RBP4 and AHSG
 ALB recombinant protein  >3 publications with RBP4 and ALB
 CYP2C9 recombinant protein  >2 publications with RBP4 and CYP2C9
 AMBP recombinant protein  >2 publications with RBP4 and AMBP
 PSMB1 recombinant protein  >2 publications with RBP4 and PSMB1
 RPE65 recombinant protein  >1 publications with RBP4 and RPE65
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Retinoid Cycle Disease Events Pathway antibodies  Retinoid Cycle Disease Events Pathway Diagram
 Retinoid Metabolism And Transport Pathway antibodies  Retinoid Metabolism And Transport Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Vitamin A And Carotenoid Metabolism Pathway antibodies  Vitamin A And Carotenoid Metabolism Pathway Diagram
 Retinoate Biosynthesis I Pathway antibodies  Retinoate Biosynthesis I Pathway Diagram
Diseases associated with RBP4 recombinant proteinOrgans/Tissues associated with RBP4 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >86 publications with RBP4 and Inflammation
 Liver Diseases Antibodies  >68 publications with RBP4 and Liver Diseases
 Fatty Liver Antibodies  >62 publications with RBP4 and Fatty Liver
 Necrosis Antibodies  >53 publications with RBP4 and Necrosis
 Hyperglycemia Antibodies  >47 publications with RBP4 and Hyperglycemia
 Kidney Diseases Antibodies  >36 publications with RBP4 and Kidney Diseases
 Glucose Intolerance Antibodies  >33 publications with RBP4 and Glucose Intolerance
 Polycystic Ovary Syndrome Antibodies  >25 publications with RBP4 and Polycystic Ovary Syndrome
 Weight Loss Antibodies  >24 publications with RBP4 and Weight Loss
 Proteinuria Antibodies  >18 publications with RBP4 and Proteinuria
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >150 publications with RBP4 and Liver
 Connective Tissue Antibodies  >109 publications with RBP4 and Connective Tissue
 Muscle Antibodies  >63 publications with RBP4 and Muscle
 Kidney Antibodies  >35 publications with RBP4 and Kidney
 Heart Antibodies  >28 publications with RBP4 and Heart
 Bone Antibodies  >16 publications with RBP4 and Bone
 Pancreas Antibodies  >14 publications with RBP4 and Pancreas
 Brain Antibodies  >11 publications with RBP4 and Brain
 Embryonic Tissue Antibodies  >11 publications with RBP4 and Embryonic Tissue
 Eye Antibodies  >10 publications with RBP4 and Eye
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