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RBP3 recombinant protein :: Retinol-binding protein 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS962924
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Retinol-binding protein 3 (RBP3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Bovine Retinol-binding protein 3

 Product Synonym Names    Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein
 Product Gene Name   

RBP3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    933-1231aa; Partial
 OMIM    180290
 3D Structure    ModBase 3D Structure for P10745
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RBP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RBP3 recombinant protein

   IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
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 SDS-Page of RBP3 recombinant protein    RBP3 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for RBP3. It may not necessarily be applicable to this product.
 NCBI GI #    4506453
 NCBI GeneID    5949
 NCBI Accession #    NP_002891.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002900.2 [Other Products]
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 UniProt Primary Accession #    P10745 [Other Products]
 UniProt Secondary Accession #    Q0QD34; Q5VSR0; Q8IXN0 [Other Products]
 UniProt Related Accession #    P10745 [Other Products]
 Molecular Weight    59.8kD
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 NCBI Official Full Name    retinol-binding protein 3
 NCBI Official Synonym Full Names    retinol binding protein 3
 NCBI Official Symbol    RBP3 [Similar Products]
 NCBI Official Synonym Symbols   
IRBP; RBPI; RP66; D10S64; D10S65; D10S66
[Similar Products]
 NCBI Protein Information    retinol-binding protein 3
 UniProt Protein Name    Retinol-binding protein 3
 UniProt Synonym Protein Names   
Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein
 Protein Family    Retinol-binding protein
 UniProt Gene Name    RBP3 [Similar Products]
 UniProt Synonym Gene Names    IRBP [Similar Products]
 UniProt Entry Name    RET3_HUMAN
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 NCBI Summary for RBP3    Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RBP3    RBP3: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Belongs to the peptidase S41A family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular region; extracellular space

Molecular Function: retinal binding; retinoid binding; retinol binding; serine-type peptidase activity

Biological Process: lipid metabolic process; phototransduction, visible light; proteolysis; retinoid metabolic process; transport; visual perception

Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 66
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Product References and Citations for RBP3 recombinant protein

   Human interstitial retinoid-binding protein. Gene structure and primary structure.Liou G.I., Ma D.-P., Yang Y.-W., Geng L., Zhu C., Baehr W.J. Biol. Chem. 264:8200-8206(1989) Characterization and comparative structural features of the gene for human interstitial retinol-binding protein.Fong S.-L., Fong W.B., Morris T.A., Kedzie K.M., Bridges C.D.B.J. Biol. Chem. 265:3648-3653(1990) Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences.Si J.S., Borst D.E., Redmond T.M., Nickerson J.M.Gene 80:99-108(1989) Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA.Fong S.-L., Bridges C.D.B.J. Biol. Chem. 263:15330-15334(1988) Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) The DNA sequence and comparative analysis of human chromosome 10.Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.Nature 429:375-381(2004)
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 Research Articles on RBP3    1. this report is the first to describe the retinal dystrophy in children caused by homozygous nonsense RBP3 mutations, highlighting the requirement for IRBP in normal eye development and visual function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RBP3 recombinant proteinDiseases associated with RBP3 recombinant protein
 Products by Pathway  Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 The Retinoid Cycle In Cones (daylight Vision) Pathway antibodies  The Retinoid Cycle In Cones (daylight Vision) Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 The Visual Cycle I (vertebrates) Pathway antibodies  The Visual Cycle I (vertebrates) Pathway Diagram
 The Visual Cycle I (vertebrates) Pathway antibodies  The Visual Cycle I (vertebrates) Pathway Diagram
 Disease Name  Pubmed Publications
 Retinal Degeneration Antibodies  >5 publications with RBP3 and Retinal Degeneration
 Retinitis Pigmentosa Antibodies  >4 publications with RBP3 and Retinitis Pigmentosa
 Hyperplasia Antibodies  >3 publications with RBP3 and Hyperplasia
 Corneal Diseases Antibodies  >1 publications with RBP3 and Corneal Diseases
 Neoplasms, Squamous Cell Antibodies  >1 publications with RBP3 and Neoplasms, Squamous Cell
 Macular Degeneration Antibodies  >1 publications with RBP3 and Macular Degeneration
Organs/Tissues associated with RBP3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >19 publications with RBP3 and Eye
 Blood Antibodies  >3 publications with RBP3 and Blood
 Muscle Antibodies  >1 publications with RBP3 and Muscle
 Brain Antibodies  >1 publications with RBP3 and Brain
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