NP_001036238.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
C-C chemokine receptor type 5
NCBI Protein Information
C-C chemokine receptor type 5; CCR-5; CC-CKR-5; C-C CKR-5; CC chemokine receptor 5
UniProt Protein Name
C-C chemokine receptor type 5
UniProt Synonym Gene Names
UniProt Entry Name
CCR5_MACMU
UniProt Comments for CCR5
Function: Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation
By similarity.
Subunit structure: Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Post-translational modification: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4
By similarity.O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen
By similarity.Palmitoylation in the C-terminal is important for cell surface expression
By similarity.Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES
By similarity.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on CCR5
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Pathways associated with CCR5 recombinant protein
Diseases associated with CCR5 recombinant protein
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