NP_001028011.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28.5 kDa
NCBI Official Full Name
CD40 ligand
NCBI Protein Information
CD40 ligand; CD40-L; CD154 protein; tumor necrosis factor ligand superfamily member 5; CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)
UniProt Protein Name
CD40 ligand
UniProt Synonym Protein Names
Tumor necrosis factor ligand superfamily member 5; CD_antigen: CD154Cleaved into the following 2 chains:CD40 ligand, membrane form; CD40 ligand, soluble form
UniProt Synonym Gene Names
UniProt Entry Name
CD40L_MACMU
UniProt Comments for CD40LG
Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching.
Research Articles on CD40LG
Precautions
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Disclaimer
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Products associated with CD40LG recombinant protein
Pathways associated with CD40LG recombinant protein
Diseases associated with CD40LG recombinant protein
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