NP_001036221.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
interleukin-1 beta
NCBI Protein Information
interleukin-1 beta; IL-1 beta
UniProt Protein Name
Interleukin-1 beta
UniProt Synonym Gene Names
UniProt Entry Name
IL1B_MACMU
UniProt Comments for IL1B
Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Subunit structure: Monomer.
Subcellular location: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Domain: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
Sequence similarities: Belongs to the IL-1 family.
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Pathways associated with IL1B recombinant protein
Diseases associated with IL1B recombinant protein
Organs/Tissues associated with IL1B recombinant protein
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