NP_001028132.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
interleukin-1 receptor accessory protein
NCBI Protein Information
interleukin-1 receptor accessory protein; IL-1RAcP; IL-1 receptor accessory protein
UniProt Protein Name
Interleukin-1 receptor accessory protein
UniProt Synonym Gene Names
UniProt Entry Name
IL1AP_MACMU
UniProt Comments for IL1RAP
Coreceptor for IL1RL2 in the IL-36 signaling system (). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system ().
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Products associated with IL1RAP recombinant protein
Pathways associated with IL1RAP recombinant protein
Diseases associated with IL1RAP recombinant protein
Organs/Tissues associated with IL1RAP recombinant protein
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