NP_001038190.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
interleukin-12 subunit beta
NCBI Protein Information
interleukin-12 subunit beta; IL-12B; CLMF p40; IL-12 subunit p40; cytotoxic lymphocyte maturation factor 40 kDa subunit
UniProt Protein Name
Interleukin-12 subunit beta
UniProt Synonym Protein Names
Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40
UniProt Synonym Gene Names
UniProt Entry Name
IL12B_MACMU
UniProt Comments for IL12B
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC
By similarity.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis
By similarity.
Subunit structure: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the type I cytokine receptor family. Type 3 subfamily.Contains 1 fibronectin type-III domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
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Pathways associated with IL12B recombinant protein
Diseases associated with IL12B recombinant protein
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