NP_001040617.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,676 Da
NCBI Official Full Name
major prion protein
NCBI Protein Information
major prion protein; prP; prP27-30; prP33-35C; major prion protein preproprotein
UniProt Protein Name
Major prion protein
UniProt Synonym Protein Names
PrP27-30; PrP33-35C; CD_antigen: CD230
UniProt Synonym Gene Names
UniProt Entry Name
PRIO_MACMU
UniProt Comments for PRNP
Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains ().
Research Articles on PRNP
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Products associated with PRNP recombinant protein
Pathways associated with PRNP recombinant protein
Diseases associated with PRNP recombinant protein
Organs/Tissues associated with PRNP recombinant protein
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