NP_001107823.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 3
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 3; NLR family pyrin domain containing 3
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 3
UniProt Entry Name
NALP3_MACMU
UniProt Comments for NLRP3
Function: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18
By similarity.
Subunit structure: Interacts with PYCARD/ASC. Part of the NALP3 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18
By similarity.
Subcellular location: Cytoplasm
By similarity.
Tissue specificity: Highly expressed in oocyte, testis, spleen, thymus and kidney. Ref.1
Sequence similarities: Belongs to the NLRP family.Contains 1 DAPIN domain.Contains 9 LRR (leucine-rich) repeats.Contains 1 NACHT domain.
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Pathways associated with NLRP3 recombinant protein
Diseases associated with NLRP3 recombinant protein
Organs/Tissues associated with NLRP3 recombinant protein
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