NP_001027980.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
pro-interleukin-16
NCBI Official Synonym Symbols
NCBI Protein Information
pro-interleukin-16; IL-16; interleukin 16 (lymphocyte chemoattractant factor)
UniProt Protein Name
Pro-interleukin-16
UniProt Synonym Protein Names
Lymphocyte chemoattractant factor
UniProt Synonym Gene Names
UniProt Entry Name
IL16_MACMU
UniProt Comments for IL16
Function: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4
By similarity.Pro-interleukin-16 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells
By similarity.
Subunit structure: Homotetramer
Probable. Pro-interleukin-16 interacts (via PDZ 2 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Pro-interleukin-16 interacts with GRIN2A. Pro-interleukin-16 interacts with GABPB1. Pro-interleukin-16 interacts (via PDZ 3 domain) with HDAC3
By similarity.
Subcellular location: Interleukin-16: Secreted
By similarity. Pro-interleukin-16: Cytoplasm. Nucleus
By similarity.
Sequence similarities: Contains 2 PDZ (DHR) domains.
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Diseases associated with IL16 recombinant protein
Organs/Tissues associated with IL16 recombinant protein
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