NP_001036241.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
prostate-specific antigen
NCBI Official Synonym Symbols
NCBI Protein Information
prostate-specific antigen; kallikrein-3; semenogelase; prostate specific antigen; kallikrein-related peptidase 3
UniProt Protein Name
Prostate-specific antigen
UniProt Synonym Protein Names
Kallikrein-3; Semenogelase
UniProt Synonym Gene Names
UniProt Entry Name
KLK3_MACMU
UniProt Comments for KLK3
Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum
By similarity.
Catalytic activity: Preferential cleavage: -Tyr-|-Xaa-.
Enzyme regulation: Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders
By similarity.
Subunit structure: Forms heterodimer with SERPINA5
By similarity.
Subcellular location: Secreted
By similarity.
Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.
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Pathways associated with KLK3 recombinant protein
Diseases associated with KLK3 recombinant protein
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