NP_001036202.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
9,448 Da
NCBI Official Full Name
selenoprotein W
NCBI Official Synonym Symbols
NCBI Protein Information
selenoprotein W
UniProt Protein Name
Selenoprotein W
UniProt Synonym Gene Names
NCBI Summary for SEPW1
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]
UniProt Comments for SEPW1
Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency ().
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Diseases associated with SEPW1 recombinant protein
Organs/Tissues associated with SEPW1 recombinant protein
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