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STK4 recombinant protein :: (Rhesus macaque) Serine/threonine-protein kinase 4 (STK4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1206454 STK4 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,285 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,745 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

(Rhesus macaque) Serine/threonine-protein kinase 4 (STK4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Macaca mulatta (Rhesus macaque) Serine/threonine-protein kinase 4 (STK4)

 Product Synonym Names    Recombinant (Rhesus macaque) Serine/threonine-protein kinase 4 (STK4); Serine/threonine-protein kinase 4 EC= 2.7.11.1 Cleaved into the following 2 chains: 1. Serine/threonine-protein kinase 4 37kDa subunit; 2. MST1/N 3. Serine/threonine-protein kinase 4 1
 Product Gene Name   

STK4 recombinant protein

[Similar Products]
 Product Synonym Gene Name    STK4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    327-487
 Sequence    SGTMVRAVGD EMGTVRVAST MTDGASTMIE HDDTLPSQLG TMVINTEDEE EEGTMKRRDE TMQPAKPSFL EYFEQKEKEN QINSFGKSVP GPLKNSSDWK IPQDGDYEFL KSWTVEDLQK RLLALDPMME QEIEEIRQKY QSKRQPILDA IEAKKRRQQN F
 Chromosome Location    Chromosome: 10; NC_007867.1 (19357840..19465780, complement). Location: chromosome: 10
 3D Structure    ModBase 3D Structure for A4K2T0
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Macaca mulatta (Rhesus macaque)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of STK4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for STK4. It may not necessarily be applicable to this product.
 NCBI GI #    274320186
 NCBI GeneID    717730
 NCBI Accession #    NP_001162148.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001168677.1 [Other Products]
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 UniProt Primary Accession #    A4K2T0 [Other Products]
 UniProt Related Accession #    A4K2T0 [Other Products]
 Molecular Weight    55,605 Da [Similar Products]
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 NCBI Official Full Name    serine/threonine-protein kinase 4
 NCBI Official Symbol    STK4 [Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase 4
 UniProt Protein Name    Serine/threonine-protein kinase 4
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    STK4 [Similar Products]
 UniProt Synonym Gene Names    MST1/N; MST1/C [Similar Products]
 UniProt Entry Name    STK4_MACMU
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 UniProt Comments for STK4    Function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes

By similarity.

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Cofactor: Magnesium

By similarity.

Enzyme regulation: Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-183. Activated by RASSF1 which acts by preventing its dephosphorylation

By similarity.

Subunit structure: Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1

By similarity.

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity. Note: The caspase-cleaved form cycles between the nucleus and cytoplasm

By similarity.

Post-translational modification: Autophosphorylated on serine and threonine residues. Phosphorylation at Thr-120 and Thr-387 by PKB/AKT1, leads to inhibition of its: kinase activity, nuclear translocation and autophosphorylation at Thr-183. It also diminishes its cleavage by caspases and its ability to phosphorylate FOXO3

By similarity.Proteolytically cleaved by caspase-3 during apoptosis at Asp-326 and Asp-349 resulting in a 37 kDa or a 39 kDa subunit respectively. The 39 kDa subunit is further cleaved into the 37 kDa form. Proteolytic cleavage results in kinase activation and nuclear translocation of the truncated form (MST1/N). It is less likely that cleavage at Asp-349 is a prerequisite for activation as this site is not conserved in the murine ortholog

By similarity.

Sequence similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 protein kinase domain.Contains 1 SARAH domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with STK4 recombinant proteinDiseases associated with STK4 recombinant protein
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Non-small Cell Lung Cancer Pathway antibodies  Non-small Cell Lung Cancer Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with STK4 and Neoplasms
 Carcinoma Antibodies  >7 publications with STK4 and Carcinoma
 Gastrointestinal Diseases Antibodies  >6 publications with STK4 and Gastrointestinal Diseases
 Neoplasms, Experimental Antibodies  >5 publications with STK4 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >4 publications with STK4 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with STK4 and Liver Diseases
 Prostatic Neoplasms Antibodies  >4 publications with STK4 and Prostatic Neoplasms
 Necrosis Antibodies  >3 publications with STK4 and Necrosis
 Liver Neoplasms, Experimental Antibodies  >3 publications with STK4 and Liver Neoplasms, Experimental
 Adenocarcinoma Antibodies  >2 publications with STK4 and Adenocarcinoma
Organs/Tissues associated with STK4 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >11 publications with STK4 and Other
 Digestive Antibodies  >3 publications with STK4 and Digestive
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