NP_001040592.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
serotonin N-acetyltransferase
NCBI Protein Information
serotonin N-acetyltransferase; AA-NAT; serotonin acetylase; arylalkylamine N-acetyltransferase; pineal arylalkylamine N-acetyltransferase
UniProt Protein Name
Serotonin N-acetyltransferase
UniProt Synonym Protein Names
Aralkylamine N-acetyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
SNAT_MACMU
UniProt Comments for AANAT
Function: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Ref.1
Catalytic activity: Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
Subunit structure: Monomer
By similarity. Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-28
By similarity. Phosphorylation on Ser-202 also allows binding to YWHAZ, but with lower affinity
By similarity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation
By similarity.
Subcellular location: Cytoplasm
By similarity.
Tissue specificity: Highly expressed in pineal gland and in the photoreceptor outer segments in the retina. Expressed at about 100-fold lower levels in the pituitary gland and testis. Not detected in other tissues. Ref.1
Induction: Exhibits night/day variations with a 10-fold increased protein levels and activity at night in the pineal gland and a 5-fold increase in the retina. In both tissues, the mRNA levels remain constant. Ref.1
Post-translational modification: cAMP-dependent phosphorylation regulates AANAT activity by promoting interaction with 14-3-3 proteins. Phosphorylation levels exhibit night/day variations, with an increase during nighttime.
Sequence similarities: Belongs to the acetyltransferase family. AANAT subfamily.Contains 1 N-acetyltransferase domain.
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Pathways associated with AANAT recombinant protein
Diseases associated with AANAT recombinant protein
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