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TRAF6 recombinant protein :: (Rhesus macaque) TNF receptor-associated factor 6 (TRAF6) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1027537 TRAF6 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $2,110 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,570 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

(Rhesus macaque) TNF receptor-associated factor 6 (TRAF6), Recombinant Protein

 Also Known As   

Recombinant Macaca mulatta (Rhesus macaque) TNF receptor-associated factor 6 (TRAF6)

 Product Gene Name   

TRAF6 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Recombinant (Rhesus macaque) TNF receptor-associated factor 6 (TRAF6); TNF receptor-associated factor 6 EC= 6.3.2.-; E3 ubiquitin-protein ligase TRAF6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-522
 Sequence    MSLLNCENSC GSSQSESDCC VAMASSCSAA TKDDSVGGTA STGNLSSSFM EDIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALV DCPQCQRPFQ KFHINIHILK DCPRRQVSCD NCAALVAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SLIPDSGYVS EVRNFQETIH QLEGRLVRQD HQIRELTAKM ETQSTYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPDLLAFQ RPTIPRNPKG FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDS GV
 Chromosome Location    Chromosome: 14; NC_007871.1 (35315275..35336097). Location: chromosome: 14
 3D Structure    ModBase 3D Structure for B6CJY5
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Macaca mulatta (Rhesus macaque)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TRAF6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TRAF6 recombinant protein

   TRAF6
NCBI/Uniprot data below describe general gene information for TRAF6. It may not necessarily be applicable to this product.
 NCBI GI #    209447040
 NCBI GeneID    716907
 NCBI Accession #    NP_001129268.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135796.1 [Other Products]
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 UniProt Primary Accession #    B6CJY5 [Other Products]
 UniProt Related Accession #    B6CJY5 [Other Products]
 Molecular Weight    59,465 Da [Similar Products]
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 NCBI Official Full Name    TNF receptor-associated factor 6
 NCBI Official Symbol    TRAF6 [Similar Products]
 NCBI Protein Information    TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6
 UniProt Protein Name    TNF receptor-associated factor 6
 UniProt Synonym Protein Names   
E3 ubiquitin-protein ligase TRAF6
 Protein Family    TNF receptor-associated factor
 UniProt Gene Name    TRAF6 [Similar Products]
 UniProt Entry Name    TRAF6_MACMU
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 UniProt Comments for TRAF6    Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation

By similarity.

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Homotrimer

By similarity. Homooligomer

By similarity. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ. Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675. Interacts with AJUBA. Interacts with TICAM1 and TICAM2. Interacts with ZFAND5. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with RBCK1

By similarity. Interacts with TRAF3IP2

By similarity. Interacts with LIMD1 (via LIM domains)

By similarity. Interacts with RSAD2/viperin

By similarity. Interacts with IFIT3 (via N-terminus)

By similarity.

Subcellular location: Cytoplasm

By similarity. Cytoplasm › cell cortex

By similarity. Nucleus

By similarity. Lipid droplet

By similarity. Note: RSAD2/viperin recruits it to the lipid droplet

By similarity.

Domain: The coiled coil domain mediates homo- and hetero-oligomerization

By similarity.The MATH/TRAF domain binds to receptor cytoplasmic domains

By similarity.

Post-translational modification: Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1

By similarity.Polyubiquitinated; after cell stimulation with IL-1-beta or TGF-beta. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form

By similarity.

Sequence similarities: Belongs to the TNF receptor-associated factor family. A subfamily.Contains 1 MATH domain.Contains 1 RING-type zinc finger.Contains 2 TRAF-type zinc fingers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TRAF6 recombinant protein
 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
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