P29451.2
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UniProt Primary Accession #
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NCBI Official Full Name
Thioredoxin
UniProt Protein Name
Thioredoxin
UniProt Synonym Gene Names
UniProt Entry Name
THIO_MACMU
UniProt Comments for TXN
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions
By similarity. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity
By similarity.
Subunit structure: Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner
By similarity.
Subcellular location: Nucleus
By similarity. Cytoplasm
By similarity. Secreted
By similarity. Note: Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus
By similarity.
Post-translational modification: In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins
By similarity.
Sequence similarities: Belongs to the thioredoxin family.Contains 1 thioredoxin domain.
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Products associated with TXN recombinant protein
Pathways associated with TXN recombinant protein
Organs/Tissues associated with TXN recombinant protein
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