NP_001123897.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
90,071 Da
NCBI Official Full Name
toll-like receptor 2
NCBI Protein Information
toll-like receptor 2
UniProt Protein Name
Toll-like receptor 2
UniProt Synonym Protein Names
CD_antigen: CD282
UniProt Comments for TLR2
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides ().
Research Articles on TLR2
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Pathways associated with TLR2 recombinant protein
Diseases associated with TLR2 recombinant protein
Organs/Tissues associated with TLR2 recombinant protein
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