NP_001027985.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tubulin beta chain
NCBI Protein Information
tubulin beta chain; tubulin beta-5 chain; tubulin beta-2B chain; tubulin, beta 2A class IIa
UniProt Protein Name
Tubulin beta chain
UniProt Synonym Protein Names
Tubulin beta-5 chain
UniProt Synonym Gene Names
UniProt Entry Name
TBB5_MACMU
UniProt Comments for TUBB
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
Subunit structure: Dimer of alpha and beta chains. May interact with RNABP10
By similarity. Interacts with PIFO
By similarity.
Subcellular location: Cytoplasm › cytoskeleton.
Tissue specificity: Ubiquitously expressed with highest levels in spleen, thymus and immature brain.
Post-translational modification: Some glutamate residues at the C-terminus are either polyglutamylated or polyglycylated. These 2 modifications occur exclusively on glutamate residues and result in either polyglutamate or polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they are regulate the assembly and dynamics of axonemal microtubules
By similarity.
Sequence similarities: Belongs to the tubulin family.
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Pathways associated with TUBB recombinant protein
Diseases associated with TUBB recombinant protein
Organs/Tissues associated with TUBB recombinant protein
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