NP_001040614.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tumor necrosis factor
NCBI Official Synonym Symbols
NCBI Protein Information
tumor necrosis factor; TNF-a; cachectin; tumor necrosis factor alpha; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor ligand superfamily member 2; ATP-binding cassette, sub-family F (GCN20), member 1
UniProt Protein Name
Tumor necrosis factor
UniProt Synonym Protein Names
Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-aCleaved into the following 6 chains:Tumor necrosis factor, membrane form; Alternative name(s):; N-terminal fragment
UniProt Synonym Gene Names
UniProt Entry Name
TNFA_MACMU
UniProt Comments for TNF
Function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells
By similarity.
Subunit structure: Homotrimer. Interacts with SPPL2B
By similarity.
Subcellular location: Cell membrane; Single-pass type II membrane protein
By similarity. Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein
By similarity. Tumor necrosis factor, soluble form: Secreted
By similarity. C-domain 1: Secreted
By similarity. C-domain 2: Secreted
By similarity.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space
By similarity.The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1
By similarity.O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid
By similarity.
Sequence similarities: Belongs to the tumor necrosis factor family.
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Pathways associated with TNF recombinant protein
Diseases associated with TNF recombinant protein
Organs/Tissues associated with TNF recombinant protein
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