NP_001028010.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 6
NCBI Protein Information
tumor necrosis factor ligand superfamily member 6; CD95 ligand; FAS antigen CD95; fas antigen ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 6
UniProt Synonym Protein Names
CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD_antigen: CD178Cleaved into the following 4 chains:Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble formAlternative name(s):Receptor-binding FasL ectodomain; Soluble Fas ligand; sFasL
UniProt Synonym Gene Names
CD95L; FASL; TNFSF6; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA [Similar Products]
UniProt Entry Name
TNFL6_MACMU
UniProt Comments for FASLG
Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
By similarity.The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition
By similarity.
Subunit structure: Homotrimer
Probable. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1
By similarity.
Subcellular location: Cell membrane; Single-pass type II membrane protein
By similarity. Cytoplasmic vesicle lumen
By similarity. Lysosome lumen
By similarity. Note: Colocalizes with the SPPL2A protease at the cell membrane. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination
By similarity.Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted
By similarity. Note: May be released into the extracellular fluid, probably by cleavage form the cell surface
By similarity.FasL intracellular domain: Nucleus
By similarity. Note: The FasL ICD cytoplasmic form is translocated into the nucleus
By similarity.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells
By similarity.Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization
By similarity.N-glycosylated
By similarity.Monoubiquitinated
By similarity.
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on FASLG
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Pathways associated with FASLG recombinant protein
Diseases associated with FASLG recombinant protein
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