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ARHGDIB recombinant protein :: Rho GDP-dissociation inhibitor 2 (ARHGDIB) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS956217 ARHGDIB recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $600 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $800 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $885 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $900 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,005 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,130 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,140 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,140 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,245 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,635 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,725 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,730 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,185 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Rho GDP-dissociation inhibitor 2 (ARHGDIB), Recombinant Protein

 Also Known As   

Recombinant Human Rho GDP-dissociation inhibitor 2 (ARHGDIB)

 Product Synonym Names    Rho GDP-dissociation inhibitor 2; Rho GDI 2; Ly-GDI; Rho-GDI beta
 Product Gene Name   

ARHGDIB recombinant protein

[Similar Products]
 Product Synonym Gene Name    ARHGDIB; GDIA2; GDID4; RAP1GN1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-201aa; Full length protein
 Sequence    TEKAPEPHV EEDDDDELDS KLNYKPPPQK SLKELQEMDK DDESLIKYKK TLLGDGPVVT DPKAPNVVVT RLTLVCESAP GPITMDLTGD LEALKKETIV LKEGSEYRVK IHFKVNRDIV SGLKYVQHTY RTGVKVDKAT FMVGSYGPRP EEYEFLTPVE EAPKGMLARG TYHNKSFFTD DDKQDHLSWE WNLSIKKEWT E
 OMIM    602843
 3D Structure    ModBase 3D Structure for P52566
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ARHGDIB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ARHGDIB. It may not necessarily be applicable to this product.
 NCBI GI #    56676393
 NCBI GeneID    397
 NCBI Accession #    NP_001166.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001175.5 [Other Products]
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 UniProt Primary Accession #    P52566 [Other Products]
 UniProt Secondary Accession #    B5BU79 [Other Products]
 UniProt Related Accession #    P52566 [Other Products]
 Molecular Weight    22,988 Da
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 NCBI Official Full Name    rho GDP-dissociation inhibitor 2
 NCBI Official Synonym Full Names    Rho GDP dissociation inhibitor (GDI) beta
 NCBI Official Symbol    ARHGDIB [Similar Products]
 NCBI Official Synonym Symbols   
D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; RhoGDI2
[Similar Products]
 NCBI Protein Information    rho GDP-dissociation inhibitor 2; Rho GDI 2; rho-GDI beta
 UniProt Protein Name    Rho GDP-dissociation inhibitor 2
 UniProt Synonym Protein Names   
Ly-GDI; Rho-GDI beta
 Protein Family    Rho GDP-dissociation inhibitor
 UniProt Gene Name    ARHGDIB [Similar Products]
 UniProt Synonym Gene Names    GDIA2; GDID4; RAP1GN1; Rho GDI 2 [Similar Products]
 UniProt Entry Name    GDIR2_HUMAN
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 NCBI Summary for ARHGDIB    Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
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 UniProt Comments for ARHGDIB    RhoGDI beta: regulates the GDP/GTP exchange reaction of Rho proteins by inhibiting the dissociation of GDP from them, keeping these small GTPases in an inactive state. The GDIs are made up of two domains: a flexible N-terminal domain of about 70 amino acid residues and a folded 134-residue C-terminal domain. Regulates the GTP/GDP cycling of glucose-responsive small GTPases. Its phosphorylation on Y156, S101, and S174 mediates the cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion. Interacts with WNK1.

Protein type: G protein regulator, misc.; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: cytoskeleton; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol

Molecular Function: Rho GDP-dissociation inhibitor activity; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; regulation of catalytic activity; multicellular organismal development; small GTPase mediated signal transduction; immune response; negative regulation of cell adhesion; cell motility; actin cytoskeleton organization and biogenesis; Rho protein signal transduction; positive regulation of GTPase activity
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 Research Articles on ARHGDIB    1. 14-3-3sigma is a RhoGDI2-regulated gene that appears to be important for suppressing the chemoresistance of gastric cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ARHGDIB recombinant proteinPathways associated with ARHGDIB recombinant protein
 Reference Product  PubMed Publications
 RAC1 recombinant protein  >23 publications with ARHGDIB and RAC1
 RHOA recombinant protein  >21 publications with ARHGDIB and RHOA
 CASP3 recombinant protein  >16 publications with ARHGDIB and CASP3
 RAC2 recombinant protein  >4 publications with ARHGDIB and RAC2
 RHOB recombinant protein  >3 publications with ARHGDIB and RHOB
 VAV1 recombinant protein  >2 publications with ARHGDIB and VAV1
 GDI2 recombinant protein  >1 publications with ARHGDIB and GDI2
 RHOH recombinant protein  >1 publications with ARHGDIB and RHOH
 Products by Pathway  Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
Diseases associated with ARHGDIB recombinant proteinOrgans/Tissues associated with ARHGDIB recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >52 publications with ARHGDIB and Neoplasms
 Carcinoma Antibodies  >16 publications with ARHGDIB and Carcinoma
 Urinary Bladder Neoplasms Antibodies  >12 publications with ARHGDIB and Urinary Bladder Neoplasms
 Breast Neoplasms Antibodies  >11 publications with ARHGDIB and Breast Neoplasms
 Lung Diseases Antibodies  >11 publications with ARHGDIB and Lung Diseases
 Lung Neoplasms Antibodies  >10 publications with ARHGDIB and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with ARHGDIB and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >4 publications with ARHGDIB and Adenocarcinoma
 Inflammation Antibodies  >4 publications with ARHGDIB and Inflammation
 Liver Neoplasms Antibodies  >4 publications with ARHGDIB and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with ARHGDIB and Blood
 Lung Antibodies  >15 publications with ARHGDIB and Lung
 Bladder Antibodies  >14 publications with ARHGDIB and Bladder
 Muscle Antibodies  >6 publications with ARHGDIB and Muscle
 Bone Antibodies  >6 publications with ARHGDIB and Bone
 Pancreas Antibodies  >6 publications with ARHGDIB and Pancreas
 Bone Marrow Antibodies  >6 publications with ARHGDIB and Bone Marrow
 Stomach Antibodies  >5 publications with ARHGDIB and Stomach
 Liver Antibodies  >4 publications with ARHGDIB and Liver
 Brain Antibodies  >3 publications with ARHGDIB and Brain
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