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ARHGEF18 recombinant protein :: Rho guanine nucleotide exchange factor 18 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS948154
SDS-PAGE
Unit / Price
0.05 mg (Yeast)  /  $120 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $135 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Rho guanine nucleotide exchange factor 18 (ARHGEF18), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Rho guanine nucleotide exchange factor 18

 Product Synonym Names    Opsin-2
 Product Gene Name   

ARHGEF18 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-36aa; Partial
 Sequence    MNGTEGPNFY VPFSNATGVV RSPFEYPQYY LAEPWQ
 OMIM    180380
 3D Structure    ModBase 3D Structure for P08100
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ARHGEF18 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ARHGEF18 recombinant protein

   Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
 Product Categories/Family for ARHGEF18 recombinant protein    Signal Transduction
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 SDS-PAGE of ARHGEF18 recombinant protein    ARHGEF18 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ARHGEF18. It may not necessarily be applicable to this product.
 NCBI GI #    4506527
 NCBI GeneID    6010
 NCBI Accession #    NP_000530.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000539.3 [Other Products]
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 UniProt Primary Accession #    P08100 [Other Products]
 UniProt Secondary Accession #    Q16414; Q2M249 [Other Products]
 UniProt Related Accession #    P08100 [Other Products]
 Molecular Weight    20.15kD
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 NCBI Official Full Name    rhodopsin
 NCBI Official Synonym Full Names    rhodopsin
 NCBI Official Symbol    RHO [Similar Products]
 NCBI Official Synonym Symbols   
RP4; OPN2; CSNBAD1
[Similar Products]
 NCBI Protein Information    rhodopsin
 UniProt Protein Name    Rhodopsin
 UniProt Synonym Protein Names   
Opsin-2
 Protein Family    Rho guanine nucleotide exchange factor
 UniProt Gene Name    RHO [Similar Products]
 UniProt Synonym Gene Names    OPN2 [Similar Products]
 UniProt Entry Name    OPSD_HUMAN
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 NCBI Summary for ARHGEF18    Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ARHGEF18    Rhodopsin: a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q21-q24

Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; intercellular junction; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; rough endoplasmic reticulum membrane

Molecular Function: G-protein coupled receptor activity; metal ion binding; photoreceptor activity; protein binding; retinal binding

Biological Process: absorption of visible light; G-protein coupled receptor protein signaling pathway; organelle organization and biogenesis; photoreceptor cell maintenance; phototransduction, visible light; protein amino acid phosphorylation; protein-chromophore linkage; red, far-red light phototransduction; regulation of rhodopsin mediated signaling; retina development in camera-type eye; retinoid metabolic process; rhodopsin mediated signaling; visual perception

Disease: Fundus Albipunctatus; Night Blindness, Congenital Stationary, Autosomal Dominant 1; Retinitis Pigmentosa 4
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Product References and Citations for ARHGEF18 recombinant protein

   "Isolation and nucleotide sequence of the gene encoding human rhodopsin." Nathans J., Hogness D.S. Proc. Natl. Acad. Sci. U.S.A. 81:4851-4855(1984)
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 Research Articles on ARHGEF18    1. Similar vacuolization in photoreceptor outer segment discs of transgenic mice expressing human rhodopsin with a T17M mutation or non-glycosylated form of rhodopsin was found. Non-glycosylated rhodopsin is unstable and is regulated via ubiquitin pathway
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ARHGEF18 recombinant proteinPathways associated with ARHGEF18 recombinant protein
 Reference Product  PubMed Publications
 GRK1 recombinant protein  >17 publications with ARHGEF18 and GRK1
 GNAT1 recombinant protein  >13 publications with ARHGEF18 and GNAT1
 SAG recombinant protein  >8 publications with ARHGEF18 and SAG
 RCVRN recombinant protein  >3 publications with ARHGEF18 and RCVRN
 RLBP1 recombinant protein  >2 publications with ARHGEF18 and RLBP1
 GNAT2 recombinant protein  >2 publications with ARHGEF18 and GNAT2
 GRK7 recombinant protein  >1 publications with ARHGEF18 and GRK7
 GNGT1 recombinant protein  >1 publications with ARHGEF18 and GNGT1
 Products by Pathway  Pathway Diagram
 Activation Of The Phototransduction Cascade Pathway antibodies  Activation Of The Phototransduction Cascade Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway antibodies  Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with ARHGEF18 recombinant proteinOrgans/Tissues associated with ARHGEF18 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1511 publications with ARHGEF18 and Inflammation
 Lung Diseases Antibodies  >1259 publications with ARHGEF18 and Lung Diseases
 Heart Diseases Antibodies  >1170 publications with ARHGEF18 and Heart Diseases
 Autoimmune Diseases Antibodies  >750 publications with ARHGEF18 and Autoimmune Diseases
 Necrosis Antibodies  >725 publications with ARHGEF18 and Necrosis
 Liver Diseases Antibodies  >652 publications with ARHGEF18 and Liver Diseases
 Fibrosis Antibodies  >641 publications with ARHGEF18 and Fibrosis
 Kidney Diseases Antibodies  >559 publications with ARHGEF18 and Kidney Diseases
 Hemorrhage Antibodies  >530 publications with ARHGEF18 and Hemorrhage
 Cell Transformation, Neoplastic Antibodies  >422 publications with ARHGEF18 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2894 publications with ARHGEF18 and Brain
 Eye Antibodies  >1290 publications with ARHGEF18 and Eye
 Uncharacterized Tissue Antibodies  >10 publications with ARHGEF18 and Uncharacterized Tissue
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