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PRPS1 recombinant protein :: Ribose-phosphate pyrophosphokinase 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS963636
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $850 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,140 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,230 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,250 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,290 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,795 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,865 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,960 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,390 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ribose-phosphate pyrophosphokinase 1 (PRPS1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Ribose-phosphate pyrophosphokinase 1

 Product Synonym Names    PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-I
 Product Gene Name   

PRPS1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-318aa; Full Length
 Sequence    PNIKIFSGSS HQDLSQKIAD RLGLELGKVV TKKFSNQETC VEIGESVRGE DVYIVQSGCG EINDNLMELL IMINACKIAS ASRVTAVIPC FPYARQDKKD KSRAPISAKL VANMLSVAGA DHIITMDLHA SQIQGFFDIP VDNLYAEPAV LKWIRENISE WRNCTIVSPD AGGAKRVTSI ADRLNVDFAL IHKERKKANE VDRMVLVGDV KDRVAILVDD MADTCGTICH AADKLLSAGA TRVYAILTHG IFSGPAISRI NNACFEAVVV TNTIPQEDKM KHCSKIQVID ISMILAEAIR RTHNGESVSY LFSHVPL
 OMIM    300661
 3D Structure    ModBase 3D Structure for P60891
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PRPS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRPS1 recombinant protein

   Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
 Product Categories/Family for PRPS1 recombinant protein    Cell Biology
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 SDS-PAGE of PRPS1 recombinant protein    PRPS1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PRPS1. It may not necessarily be applicable to this product.
 NCBI GI #    324711015
 NCBI GeneID    5631
 NCBI Accession #    NP_001191331.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001204402.1 [Other Products]
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 UniProt Primary Accession #    P60891 [Other Products]
 UniProt Secondary Accession #    P09329; B1ALA8; B2R6T7; B4DNL6; D3DUX6 [Other Products]
 UniProt Related Accession #    P60891 [Other Products]
 Molecular Weight    50.68kD
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 NCBI Official Full Name    ribose-phosphate pyrophosphokinase 1 isoform 2
 NCBI Official Synonym Full Names    phosphoribosyl pyrophosphate synthetase 1
 NCBI Official Symbol    PRPS1 [Similar Products]
 NCBI Official Synonym Symbols   
ARTS; DFN2; PRSI; CMTX5; DFNX1; PRS-I; PPRibP
[Similar Products]
 NCBI Protein Information    ribose-phosphate pyrophosphokinase 1
 UniProt Protein Name    Ribose-phosphate pyrophosphokinase 1
 UniProt Synonym Protein Names   
PPRibP; Phosphoribosyl pyrophosphate synthase I; PRS-I
 Protein Family    Ribose-phosphate pyrophosphokinase
 UniProt Gene Name    PRPS1 [Similar Products]
 UniProt Synonym Gene Names    PRS-I [Similar Products]
 UniProt Entry Name    PRPS1_HUMAN
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 NCBI Summary for PRPS1    This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
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 UniProt Comments for PRPS1    PRPS1: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. Defects in PRPS1 are the cause of phosphoribosylpyrophosphate synthetase superactivity (PRPS1 superactivity); also known as PRPS-related gout. It is a familial disorder characterized by excessive purine production, gout and uric acid urolithiasis. Defects in PRPS1 are the cause of Charcot-Marie-Tooth disease X-linked recessive type 5 (CMTX5); also known as optic atrophy-polyneuropathy-deafness or Rosenberg-Chutorian syndrome. CMTX5 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. Defects in PRPS1 are the cause of ARTS syndrome (ARTS); also known as fatal ataxia X-linked with deafness and loss of vision. ARTS is a disorder characterized by mental retardation, early-onset hypotonia, ataxia, delayed motor development, hearing impairment, and optic atrophy. Susceptibility to infections, especially of the upper respiratory tract, can result in early death. Defects in PRPS1 are the cause of deafness X-linked type 1 (DFNX1); also known as congenital sensorineural deafness X-linked 2 (DFN2). It is a form of deafness characterized by progressive, severe-to-profound sensorineural hearing loss in males. Females manifest mild to moderate hearing loss. Belongs to the ribose-phosphate pyrophosphokinase family.

Protein type: EC 2.7.6.1; Nucleotide Metabolism - purine; Kinase, other; Carbohydrate Metabolism - pentose phosphate pathway

Chromosomal Location of Human Ortholog: Xq22.3

Cellular Component: cytosol

Molecular Function: ADP binding; AMP binding; ATP binding; carbohydrate binding; GDP binding; kinase activity; magnesium ion binding; protein binding; protein homodimerization activity; ribose phosphate diphosphokinase activity

Biological Process: 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; carbohydrate metabolic process; hypoxanthine biosynthetic process; nervous system development; organ regeneration; phosphorylation; purine base metabolic process; purine nucleotide biosynthetic process; pyrimidine nucleotide biosynthetic process

Disease: Arts Syndrome; Charcot-marie-tooth Disease, X-linked Recessive, 5; Phosphoribosylpyrophosphate Synthetase Superactivity
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Product References and Citations for PRPS1 recombinant protein

   Cloning of two distinct copies of human phosphoribosylpyrophosphate synthetase cDNA.Roessler B.J., Bell G., Heidler S., Seino S., Becker M., Palella T.D.Nucleic Acids Res. 18:193-193(1990) Complete nucleotide sequence of human phosphoribosyl pyrophosphate synthetase subunit I (PRS I) cDNA and a comparison with human and rat PRPS gene families.Sonoda T., Taira M., Ishijima S., Ishizuka T., Iizaka T., Tatibana M.J. Biochem. 109:361-364(1991) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004) The DNA sequence of the human X chromosome.Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.Nature 434:325-337(2005)
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 Research Articles on PRPS1    1. Females with a missense mutation in PRPS1, exhibit neuropathy, hearing loss and retinopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRPS1 recombinant proteinDiseases associated with PRPS1 recombinant protein
 Reference Product  PubMed Publications
 PRPS2 recombinant protein  >10 publications with PRPS1 and PRPS2
 HPRT1 recombinant protein  >3 publications with PRPS1 and HPRT1
 PRPSAP2 recombinant protein  >1 publications with PRPS1 and PRPSAP2
 PRPSAP1 recombinant protein  >1 publications with PRPS1 and PRPSAP1
 Disease Name  Pubmed Publications
 Arts syndrome Antibodies  >12 publications with PRPS1 and Arts syndrome
 Deafness, X-Linked 1 Antibodies  >9 publications with PRPS1 and Deafness, X-Linked 1
 Phosphoribosylpyrophosphate Synthetase Superactivity Antibodies  >4 publications with PRPS1 and Phosphoribosylpyrophosphate Synthetase Superactivity
 Neurobehavioral Manifestations Antibodies  >3 publications with PRPS1 and Neurobehavioral Manifestations
 Fetal Growth Retardation Antibodies  >1 publications with PRPS1 and Fetal Growth Retardation
 Hypertrophy Antibodies  >1 publications with PRPS1 and Hypertrophy
 Kidney Diseases Antibodies  >1 publications with PRPS1 and Kidney Diseases
Organs/Tissues associated with PRPS1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with PRPS1 and Blood
 Brain Antibodies  >5 publications with PRPS1 and Brain
 Muscle Antibodies  >3 publications with PRPS1 and Muscle
 Heart Antibodies  >2 publications with PRPS1 and Heart
 Liver Antibodies  >2 publications with PRPS1 and Liver
 Embryonic Tissue Antibodies  >2 publications with PRPS1 and Embryonic Tissue
 Ear Antibodies  >2 publications with PRPS1 and Ear
 Testis Antibodies  >2 publications with PRPS1 and Testis
 Adrenal Gland Antibodies  >1 publications with PRPS1 and Adrenal Gland
 Eye Antibodies  >1 publications with PRPS1 and Eye
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