NP_071524.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
180,748 Da
NCBI Official Full Name
roundabout homolog 1
NCBI Official Synonym Full Names
roundabout guidance receptor 1
NCBI Protein Information
roundabout homolog 1
UniProt Protein Name
Roundabout homolog 1
NCBI Summary for Robo1
putative axon guidance receptor [RGD, Feb 2006]
UniProt Comments for Robo1
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (). May be required for lung development ().
Research Articles on Robo1
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Products associated with Robo1 recombinant protein
Pathways associated with Robo1 recombinant protein
Diseases associated with Robo1 recombinant protein
Organs/Tissues associated with Robo1 recombinant protein
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