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S100A1 recombinant protein :: S100 Calcium Binding Protein A1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142919 S100A1 recombinant protein
Unit / Price
0.005 mg  /  $265 +1 FREE 8GB USB
0.01 mg  /  $365 +1 FREE 8GB USB
0.025 mg  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S100 Calcium Binding Protein A1 (S100A1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human S100 Calcium Binding Protein A1

 Product Synonym Names    S100A1 Human; S100 Calcium Binding Protein A1 Human Recombinant; Protein S100-A1; S100 calcium-binding protein A1; S-100 protein alpha subunit; S-100 protein alpha chain; S100A1; S100A; S100; S100-alpha; S100-A1
 Product Gene Name   

S100A1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MKHHHHHHAS GS ELETAMET LINVFHAHSG KEGDKYKLSK KELKELLQTE LSGFLDAQKD VDAVDKVMKE LDENGDGEVD FQEYVVLVAA LTVACNNFFW ENS.
 OMIM    176940
 3D Structure    ModBase 3D Structure for P23297
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The S100A1 protein was lyophilized from 0.4 um filtered solution at a concentration of 0.5mg/ml containing 20mM Tris pH-7.5 and 50mM NaCl.
White lyophilized (freeze-dried) powder.
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 Solubility    Add deionized water to a working concentration approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Lyophilized S100A1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution S100A1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of S100A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for S100A1 recombinant protein

   Description: S100A1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 103 amino acids which include a 10 amino acid His Tag fused at N-terminus and having a total molecular mass of 11.66 kDa. S100A1 Human Recombinant is purified by proprietary chromatographic techniques.

Introduction: S100A1 is a member of the S100 family of calcium binding proteins with EF-hand type Ca+2 binding motive. S100A1 (Calcium Binding Protein A1) is involved in the activation of sarcoplasmatic calcium release and the regulation of intermediate filament polymerization. S100A1 may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of S100A1 has been implicated in cardiomyopathies.S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. There are at least 13 members in the S100 gene family, which are located as a cluster on chromosome 1q21.
 Product Categories/Family for S100A1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Calcium Binding Protein
NCBI/Uniprot data below describe general gene information for S100A1. It may not necessarily be applicable to this product.
 NCBI GI #    5454032
 NCBI GeneID    6271
 NCBI Accession #    NP_006262.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006271.1 [Other Products]
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 UniProt Primary Accession #    P23297 [Other Products]
 UniProt Secondary Accession #    Q5T7Y3; B2R5D9 [Other Products]
 UniProt Related Accession #    P23297 [Other Products]
 Molecular Weight    10,546 Da
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 NCBI Official Full Name    protein S100-A1
 NCBI Official Synonym Full Names    S100 calcium binding protein A1
 NCBI Official Symbol    S100A1 [Similar Products]
 NCBI Official Synonym Symbols   
S100; S100A; S100-alpha
[Similar Products]
 NCBI Protein Information    protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 alpha; S100 calcium-binding protein A1; S100 protein, alpha polypeptide
 UniProt Protein Name    Protein S100-A1
 UniProt Synonym Protein Names   
S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1
 Protein Family    Protein
 UniProt Gene Name    S100A1 [Similar Products]
 UniProt Synonym Gene Names    S100A [Similar Products]
 UniProt Entry Name    S10A1_HUMAN
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 NCBI Summary for S100A1    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
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 UniProt Comments for S100A1    S100A1: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Interacts with AGER and CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. Belongs to the S-100 family.

Protein type: Endoplasmic reticulum; Calcium-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: neuron projection; protein complex; sarcoplasmic reticulum; M band; nucleus; Z disc

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; calcium ion binding; calcium-dependent protein binding; ATPase binding

Biological Process: substantia nigra development; negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction
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 Research Articles on S100A1    1. Patients with acute myocardial infarction (MI) showed significantly increased S100A1 serum levels. S100A1 signaling in cardiac fibroblasts occurs through endosomal TLR4/MyD88.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with S100A1 recombinant proteinDiseases associated with S100A1 recombinant protein
 Reference Product  PubMed Publications
 S100B recombinant protein  >92 publications with S100A1 and S100B
 S100A4 recombinant protein  >39 publications with S100A1 and S100A4
 RYR1 recombinant protein  >19 publications with S100A1 and RYR1
 S100P recombinant protein  >16 publications with S100A1 and S100P
 ATP2A2 recombinant protein  >13 publications with S100A1 and ATP2A2
 GFAP recombinant protein  >12 publications with S100A1 and GFAP
 TP53 recombinant protein  >1 publications with S100A1 and TP53
 ANXA6 recombinant protein  >1 publications with S100A1 and ANXA6
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >50 publications with S100A1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >44 publications with S100A1 and Heart Diseases
 Ischemia Antibodies  >17 publications with S100A1 and Ischemia
 Hypertrophy Antibodies  >16 publications with S100A1 and Hypertrophy
 Kidney Diseases Antibodies  >16 publications with S100A1 and Kidney Diseases
 Disease Models, Animal Antibodies  >16 publications with S100A1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >15 publications with S100A1 and Neoplasm Metastasis
 Inflammation Antibodies  >10 publications with S100A1 and Inflammation
 Breast Neoplasms Antibodies  >9 publications with S100A1 and Breast Neoplasms
 Hypertension Antibodies  >6 publications with S100A1 and Hypertension
Organs/Tissues associated with S100A1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >101 publications with S100A1 and Muscle
 Heart Antibodies  >80 publications with S100A1 and Heart
 Brain Antibodies  >62 publications with S100A1 and Brain
 Skin Antibodies  >28 publications with S100A1 and Skin
 Kidney Antibodies  >21 publications with S100A1 and Kidney
 Lung Antibodies  >10 publications with S100A1 and Lung
 Embryonic Tissue Antibodies  >10 publications with S100A1 and Embryonic Tissue
 Connective Tissue Antibodies  >8 publications with S100A1 and Connective Tissue
 Bone Antibodies  >7 publications with S100A1 and Bone
 Eye Antibodies  >6 publications with S100A1 and Eye
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