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mS100A8 recombinant protein :: S100 Calcium Binding Protein A8 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144695 mS100A8 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S100 Calcium Binding Protein A8 (mS100A8), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse S100 Calcium Binding Protein A8

 Product Synonym Names    S100A8 Mouse; S100 Calcium Binding Protein A8 Mouse Recombinant; Calgranulin A; MRP8; CAGA; CGLA; CFAG; Protein S100-A8; S100 calcium-binding protein A8; Migration inhibitory factor-related protein 8; MRP-8; p8; Cystic fibrosis antigen; Leukocyte L1 complex light chain; Calprotectin L1L subunit; Urinary stone protein band A; S100A8; MIF; NIF; L1Ag; CP-10; MA387; 60B8AG
 Product Gene Name   

mS100A8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MPSELEKALS NLIDVYHNYS NIQGNHHALY KNDFKKMVTT ECPQFVQNIN IENLFRELDI NSDNAINFEE FLAMVIKVGV ASHKDSHKE
 3D Structure    ModBase 3D Structure for P27005
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    S100A8 protein solution (1mg/1ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.1M NaCl and 1mM DTT.
Sterile Filtered clear solution.
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 Other Notes    Small volumes of mS100A8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for mS100A8 recombinant protein

   Description: S100A8 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 109 amino acids (1-89a.a) and having a molecular mass of 12.4kDa.S100A8 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: S100A8 is a part of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a broad range of cells, and participate in the regulation of cellular processes such as cell cycle progression and differentiation. S100A8 plays a role in the inhibition of casein kinase and as a cytokine. S100A8 altered expression is related with cystic fibrosis disease. S100A8 is a calcium-binding protein that has antimicrobial activity against bacteria and fungi.S100A8 is crucial for resistance towards invasion by pathogenic bacteria. S100A8 up-regulates transcription of genes that are under the control of NF-kappa-B. S100A8 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide. S100A8 endorses tubulin polymerization and promotes phagocyte migration and infiltration of granulocytes at sites of wounding. S100A8 takes part as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.
 Product Categories/Family for mS100A8 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Calcium Binding Protein
NCBI/Uniprot data below describe general gene information for mS100A8. It may not necessarily be applicable to this product.
 NCBI GI #    7305453
 NCBI GeneID    20201
 NCBI Accession #    NP_038678.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013650.2 [Other Products]
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 UniProt Primary Accession #    P27005 [Other Products]
 UniProt Secondary Accession #    P31724 [Other Products]
 UniProt Related Accession #    P27005 [Other Products]
 Molecular Weight    10,295 Da
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 NCBI Official Full Name    protein S100-A8
 NCBI Official Synonym Full Names    S100 calcium binding protein A8 (calgranulin A)
 NCBI Official Symbol    S100a8 [Similar Products]
 NCBI Official Synonym Symbols   
p8; B8Ag; CFAg; Caga; MRP8; CP-10; 60B8Ag; AI323541
[Similar Products]
 NCBI Protein Information    protein S100-A8; MRP-8; S100 calcium-binding protein A8; calgranulin-A; chemotactic S100 protein; chemotactic cytokine CP-10; leukocyte L1 complex light chain; migration inhibitory factor-related protein 8; pro-inflammatory S100 cytokine
 UniProt Protein Name    Protein S100-A8
 UniProt Synonym Protein Names   
Calgranulin-A; Chemotactic cytokine CP-10; Leukocyte L1 complex light chain; Migration inhibitory factor-related protein 8; MRP-8; p8; Pro-inflammatory S100 cytokine; S100 calcium-binding protein A8
 UniProt Gene Name    S100a8 [Similar Products]
 UniProt Synonym Gene Names    Caga; Mrp8; MRP-8; p8 [Similar Products]
 UniProt Entry Name    S10A8_MOUSE
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 UniProt Comments for mS100A8    S100A8: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF- kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Belongs to the S-100 family.

Cellular Component: extracellular space; cytoskeleton; membrane; cytoplasm; plasma membrane; extracellular region; nucleus

Molecular Function: arachidonic acid binding; antioxidant activity; RAGE receptor binding; zinc ion binding; microtubule binding; metal ion binding; calcium ion binding

Biological Process: caspase activation; neutrophil chemotaxis; apoptosis; immune system process; regulation of inflammatory response; innate immune response; autophagy; positive regulation of peptide secretion; chemotaxis; inflammatory response; leukocyte migration during inflammatory response; positive regulation of inflammatory response
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 Research Articles on mS100A8    1. Calprotectin heterodimer of subunits S100A8 (and S100A9 ) is detectable within 6 h of infection as immune cells respond to the invading pathogen.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with mS100A8 recombinant proteinOrgans/Tissues associated with mS100A8 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >410 publications with mS100A8 and Inflammation
 Fibrosis Antibodies  >103 publications with mS100A8 and Fibrosis
 Disease Models, Animal Antibodies  >95 publications with mS100A8 and Disease Models, Animal
 Necrosis Antibodies  >80 publications with mS100A8 and Necrosis
 Cardiovascular Diseases Antibodies  >75 publications with mS100A8 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >60 publications with mS100A8 and Nervous System Diseases
 Heart Diseases Antibodies  >30 publications with mS100A8 and Heart Diseases
 Kidney Diseases Antibodies  >25 publications with mS100A8 and Kidney Diseases
 Breast Neoplasms Antibodies  >25 publications with mS100A8 and Breast Neoplasms
 Lung Neoplasms Antibodies  >25 publications with mS100A8 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >112 publications with mS100A8 and Lung
 Brain Antibodies  >55 publications with mS100A8 and Brain
 Bone Marrow Antibodies  >52 publications with mS100A8 and Bone Marrow
 Joint Antibodies  >50 publications with mS100A8 and Joint
 Kidney Antibodies  >43 publications with mS100A8 and Kidney
 Liver Antibodies  >42 publications with mS100A8 and Liver
 Lymph Node Antibodies  >30 publications with mS100A8 and Lymph Node
 Spleen Antibodies  >19 publications with mS100A8 and Spleen
 Eye Antibodies  >18 publications with mS100A8 and Eye
 Embryonic Tissue Antibodies  >18 publications with mS100A8 and Embryonic Tissue
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