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mS100b recombinant protein :: S100 Calcium Binding Protein B Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144086 mS100b recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S100 Calcium Binding Protein B (mS100b), Recombinant Protein

 Also Known As   

Recombinant Mouse S100 Calcium Binding Protein B

 Product Synonym Names    S100b Mouse; S100 Calcium Binding Protein B Mouse Recombinant; Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B; Bpb; AI850290; MGC74317; S100b
 Product Gene Name   

mS100b recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEVVDKVMET LDEDGDGECD FQEFMAFVAM VTTACHEFFE HE
 3D Structure    ModBase 3D Structure for P50114
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 Host    E Coli
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 Purity/Purification    Greater than 85.0% as determined by SDS-PAGE.
 Form/Format    S100B Mouse solution containing 20mM Tris-HCl pH-8, 1mM DTT & 10% glycerol.
Sterile filtered colorless solution.
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 Other Notes    Small volumes of mS100b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for mS100b recombinant protein

   Description: S100B Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 92 amino acids (1-112 a.a.) and having a molecular mass of 12.8 kDa. The Mouse S100B is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: S100B faintly binds calcium but binds zinc extremely strongly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. S100B binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction participates in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
 Product Categories/Family for mS100b recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Calcium Binding Protein
NCBI/Uniprot data below describe general gene information for mS100b. It may not necessarily be applicable to this product.
 NCBI GI #    6677839
 NCBI GeneID    20203
 NCBI Accession #    NP_033141.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_009115.3 [Other Products]
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 UniProt Primary Accession #    P50114 [Other Products]
 UniProt Related Accession #    P50114 [Other Products]
 Molecular Weight    10,728 Da
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 NCBI Official Full Name    protein S100-B
 NCBI Official Synonym Full Names    S100 protein, beta polypeptide, neural
 NCBI Official Symbol    S100b [Similar Products]
 NCBI Official Synonym Symbols   
Bpb; AI850290
[Similar Products]
 NCBI Protein Information    protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B
 UniProt Protein Name    Protein S100-B
 UniProt Synonym Protein Names   
S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B
 UniProt Gene Name    S100b [Similar Products]
 UniProt Entry Name    S100B_MOUSE
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 UniProt Comments for mS100b    S100B: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family.

Protein type: Calcium-binding

Cellular Component: ruffle; extracellular space; intracellular membrane-bound organelle; cell soma; perinuclear region of cytoplasm; cytoplasm; extracellular region; nucleus

Molecular Function: identical protein binding; RAGE receptor binding; protein homodimerization activity; zinc ion binding; metal ion binding; calcium ion binding; calcium-dependent protein binding; receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; cellular calcium ion homeostasis; regulation of cell shape; learning and/or memory; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; positive regulation of cell proliferation; energy reserve metabolic process; positive regulation of synaptic transmission; memory; regulation of cytokine biosynthetic process; regulation of neuronal synaptic plasticity
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 Research Articles on mS100b    1. Data suggest up-regulation of S100b/RAGE (advanced glycosylation end-product receptor) signaling plays role in inflammatory interaction between adipocytes/macrophages; adipocyte secretion of S100b is up-regulated by Tnf (tumor necrosis factor-alpha).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with mS100b recombinant proteinPathways associated with mS100b recombinant protein
 Reference Product  PubMed Publications
 Gfap recombinant protein  >167 publications with mS100b and Gfap
 App recombinant protein  >17 publications with mS100b and App
 Trp53 recombinant protein  >6 publications with mS100b and Trp53
 Iqgap1 recombinant protein  >3 publications with mS100b and Iqgap1
 Ager recombinant protein  >2 publications with mS100b and Ager
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 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
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 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
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 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
Diseases associated with mS100b recombinant proteinOrgans/Tissues associated with mS100b recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >646 publications with mS100b and Nervous System Diseases
 Brain Diseases Antibodies  >532 publications with mS100b and Brain Diseases
 Cardiovascular Diseases Antibodies  >238 publications with mS100b and Cardiovascular Diseases
 Brain Injuries Antibodies  >188 publications with mS100b and Brain Injuries
 Inflammation Antibodies  >143 publications with mS100b and Inflammation
 Brain Ischemia Antibodies  >117 publications with mS100b and Brain Ischemia
 Disease Models, Animal Antibodies  >112 publications with mS100b and Disease Models, Animal
 Hemorrhage Antibodies  >78 publications with mS100b and Hemorrhage
 Heart Diseases Antibodies  >69 publications with mS100b and Heart Diseases
 Necrosis Antibodies  >57 publications with mS100b and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >915 publications with mS100b and Brain
 Skin Antibodies  >60 publications with mS100b and Skin
 Eye Antibodies  >35 publications with mS100b and Eye
 Spinal Cord Antibodies  >26 publications with mS100b and Spinal Cord
 Embryonic Tissue Antibodies  >15 publications with mS100b and Embryonic Tissue
 Joint Antibodies  >11 publications with mS100b and Joint
 Thyroid Antibodies  >9 publications with mS100b and Thyroid
 Prostate Antibodies  >5 publications with mS100b and Prostate
 Pineal Gland Antibodies  >2 publications with mS100b and Pineal Gland
 Uterus Antibodies  >2 publications with mS100b and Uterus
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