Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow SDF-1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • IFNG Antibody
 • ApoA-I Native Protein
 • CD83 antigen (CD83) ELISA Kit
 • Serine--pyruvate aminotransferase (AGXT) Recombinant Protein
 • Osteocalcin (Bglap) ELISA Kit
 • sIL-6R ELISA Kit
 • CD20 Antibody
 • CD44 Antibody
 • IL-17D (IL17D) ELISA Kit
 • DDX50 Antibody
 • OIT3 ELISA Kit
 • Treponema pallidum Antibody
 • allograft inflammatory factor 1 (AIF1) ELISA Kit
 • grancalcin, EF-hand calcium binding protein (GCA) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SDF-1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203323
SDS-Page
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SDF-1, Recombinant Protein

★Popular Item★
 Also Known As   

SDF-1, 22-93aa, Human, His tag, E Coli

 Product Synonym Names    Stromal cell-derived factor 1; SDF-1; Stromal cell-derived factor 1; CXCL12; PBSF; hIRH; Stromal cell-derived factor 1 C-X-C motif chemokine 12; OTTHuMP00000019491; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; Chemokine (C-X-C motif) ligand 12; Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); Intercrine reduced in hepatomas IRH; Chemokine CXC motif ligand 12; SDF1A; SDF1B; Pre-B cell growth-stimulating factor; SCYB12; SDF 1; Stromal cell-derived factor 1 delta; SDF-1a; SDF-1b; Stromal cell-derived factor 1 gamma; Stromal cell-derived factor 1a; Stromal cell-derived factor-1 alpha; Thymic lymphoma cell-stimulating factor; Tlsf; TLSF-a; TLSF-b; Tlsfa; Tlsfb; TPAR1.
 Product Gene Name   

SDF-1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHHHHH SSGLVPRGSH MKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKR FKM
 OMIM    L36033 mRNA
 3D Structure    ModBase 3D Structure for P48061
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
 Concentration    0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)
Section Bar
 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
Section Bar
 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SDF-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for SDF-1 recombinant protein

   SDF-1 is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12). SDF-1 is strongly chemotactic for lymphocytes and works by its receptor CXCR4. The SDF-1+CXCR4 complex plays a significant role in the creation of metastases of neoplasms and as a response to cytostatic treatment. Identification of this complex may be a useful prognostic factor in the therapy of many types of carcinoma. Recombinant human SDF-1, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for SDF-1 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for SDF-1 recombinant protein   

SDS-PAGE

Section Bar
 SDS-Page of SDF-1 recombinant protein    SDF-1 recombinant protein SDS-Page image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SDF-1. It may not necessarily be applicable to this product.
 NCBI GI #    10834988
 NCBI GeneID    6387
 NCBI Accession #    NP_000600 [Other Products]
 NCBI GenBank Nucleotide #    NM_000609.6 [Other Products]
Section Bar
 UniProt Primary Accession #    P48061 [Other Products]
 UniProt Secondary Accession #    Q2L985; Q2L986; Q2L988; Q5IT36; Q6ICW0; Q9H554; B2R4G0; E7EVL0; H7BYN8 [Other Products]
 UniProt Related Accession #    P48061 [Other Products]
 Molecular Weight    10.8 kDa (93aa), confirmed by MALDI-TOF
Table BarTOPTable Bar
 NCBI Official Full Name    stromal cell-derived factor 1 isoform beta
 NCBI Official Synonym Full Names    C-X-C motif chemokine ligand 12
 NCBI Official Symbol    CXCL12 [Similar Products]
 NCBI Official Synonym Symbols   
IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
[Similar Products]
 NCBI Protein Information    stromal cell-derived factor 1
 UniProt Protein Name    Stromal cell-derived factor 1
 UniProt Synonym Protein Names   
C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH
 UniProt Gene Name    CXCL12 [Similar Products]
 UniProt Synonym Gene Names    SDF1; SDF1A; SDF1B; SDF-1; hSDF-1; IRH; hIRH; PBSF [Similar Products]
Section Bar
 NCBI Summary for SDF-1    This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Section Bar
 UniProt Comments for SDF-1    Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
Table BarTOPTable Bar
 

Product References and Citations for SDF-1 recombinant protein

   Arya M., et al. (2007). Tumour Biol. 28 (3):123-31.; Kucia M., et al. (2005). Stem Cells. 23 (7):879-94.;
Section Bar
 Research Articles on SDF-1    1. The combination of FTY720 with the SPHK1 inhibitor SKI-II results in synergistic inhibition of MM growth. CXCR4/CXCL12-enhanced expression correlates with reduced MM cell sensitivity to both FTY720 and SKI-II inhibitors, and with SPHK1 coexpression in both cell lines and primary MM bone marrow (BM) samples, suggesting regulative cross-talk between the CXCR4/CXCL12 and SPHK1 pathways in MM cells
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with SDF-1 recombinant proteinPathways associated with SDF-1 recombinant protein
 Reference Product  PubMed Publications
 CXCR4 recombinant protein  >4253 publications with SDF-1 and CXCR4
 CXCR7 recombinant protein  >428 publications with SDF-1 and CXCR7
 CCR5 recombinant protein  >320 publications with SDF-1 and CCR5
 CCL5 recombinant protein  >289 publications with SDF-1 and CCL5
 CCR2 recombinant protein  >190 publications with SDF-1 and CCR2
 CCR7 recombinant protein  >176 publications with SDF-1 and CCR7
 HIF1A recombinant protein  >114 publications with SDF-1 and HIF1A
 CCR4 recombinant protein  >48 publications with SDF-1 and CCR4
 IL8 recombinant protein  >44 publications with SDF-1 and IL8
 CXCR1 recombinant protein  >43 publications with SDF-1 and CXCR1
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with SDF-1 recombinant proteinOrgans/Tissues associated with SDF-1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >810 publications with SDF-1 and Inflammation
 Cardiovascular Diseases Antibodies  >766 publications with SDF-1 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >553 publications with SDF-1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >354 publications with SDF-1 and Breast Neoplasms
 Heart Diseases Antibodies  >347 publications with SDF-1 and Heart Diseases
 Ischemia Antibodies  >319 publications with SDF-1 and Ischemia
 Neoplasm Invasiveness Antibodies  >318 publications with SDF-1 and Neoplasm Invasiveness
 Necrosis Antibodies  >286 publications with SDF-1 and Necrosis
 HIV Infections Antibodies  >284 publications with SDF-1 and HIV Infections
 Adenocarcinoma Antibodies  >225 publications with SDF-1 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1967 publications with SDF-1 and Bone
 Bone Marrow Antibodies  >1758 publications with SDF-1 and Bone Marrow
 Vascular Antibodies  >1407 publications with SDF-1 and Vascular
 Brain Antibodies  >670 publications with SDF-1 and Brain
 Muscle Antibodies  >475 publications with SDF-1 and Muscle
 Lung Antibodies  >460 publications with SDF-1 and Lung
 Heart Antibodies  >423 publications with SDF-1 and Heart
 Liver Antibodies  >379 publications with SDF-1 and Liver
 Embryonic Tissue Antibodies  >260 publications with SDF-1 and Embryonic Tissue
 Skin Antibodies  >211 publications with SDF-1 and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions