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SDF-1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203323
SDS-PAGE
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SDF-1, Recombinant Protein

 Also Known As   

SDF-1, 22-93aa, Human, His-tag, Recombinant, E Coli

 Product Synonym Names    SDF-1; Stromal cell-derived factor 1; CXCL12; PBSF; hIRH; Stromal cell-derived factor 1 C-X-C motif chemokine 12; OTTHuMP00000019491; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; AI174028; Chemokine (C-X-C motif) ligand 12; Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); Intercrine reduced in hepatomas IRH; Chemokine CXC motif ligand 12; SDF1A; SDF1B; Pre-B cell growth-stimulating factor; SCYB12; SDF 1; Stromal cell-derived factor 1 delta; SDF-1a; SDF-1b; Stromal cell-derived factor 1 gamma; Stromal cell-derived factor 1a; Stromal cell-derived factor-1 alpha; Thymic lymphoma cell-stimulating factor; Tlsf; TLSF-a; TLSF-b; Tlsfa; Tlsfb; TPAR1.
 Product Gene Name   

SDF-1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKR FKM
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
 Endotoxin    < 1.0 Eu per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SDF-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SDF-1 recombinant protein

   SDF-1 is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12). SDF-1 is strongly chemotactic for lymphocytes and works by its receptor CXCR4. The SDF-1+CXCR4 complex plays a significant role in the creation of metastases of neoplasms and as a response to cytostatic treatment. Identification of this complex may be a useful prognostic factor in the therapy of many types of carcinoma. Recombinant human SDF-1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for SDF-1 recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for SDF-1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of SDF-1 recombinant protein    SDF-1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for SDF-1. It may not necessarily be applicable to this product.
 NCBI GI #    10834988
 NCBI GeneID    6387
 NCBI Accession #    NP_000600 [Other Products]
 NCBI GenBank Nucleotide #    NM_000609.6 [Other Products]
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 UniProt Secondary Accession #    Q2L985; Q2L986; Q2L988; Q5IT36; Q6ICW0; Q9H554; B2R4G0; E7EVL0; H7BYN8 [Other Products]
 UniProt Related Accession #    P48061 [Other Products]
 Molecular Weight    10.8 kDa (93aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    stromal cell-derived factor 1 isoform beta
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 12
 NCBI Official Symbol    CXCL12 [Similar Products]
 NCBI Official Synonym Symbols   
IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
[Similar Products]
 NCBI Protein Information    stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor
 UniProt Protein Name    Stromal cell-derived factor 1
 UniProt Synonym Protein Names   
C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF
 UniProt Gene Name    CXCL12 [Similar Products]
 UniProt Synonym Gene Names    SDF1; SDF1A; SDF1B; SDF-1; hSDF-1; IRH; hIRH; PBSF [Similar Products]
 UniProt Entry Name    SDF1_HUMAN
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 NCBI Summary for SDF-1    This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
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 UniProt Comments for SDF-1    CXCL12: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1- alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3- 67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T- cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N- terminus of CXCR7. Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen. Belongs to the intercrine alpha (chemokine CxC) family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Chemokine; Cell development/differentiation; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q11.1

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: growth factor activity; chemokine activity; chemokine receptor binding; CXCR chemokine receptor binding; receptor binding

Biological Process: response to peptide hormone stimulus; positive regulation of dopamine secretion; positive regulation of cell adhesion; blood circulation; adult locomotory behavior; neuron migration; motor axon guidance; signal transduction; chemotaxis; induction of positive chemotaxis; germ cell development; T cell proliferation; response to radiation; germ cell migration; cell adhesion; organ regeneration; regulation of actin polymerization and/or depolymerization; response to virus; cellular calcium ion homeostasis; patterning of blood vessels; G-protein coupled receptor protein signaling pathway; response to mechanical stimulus; response to heat; ameboidal cell migration; positive regulation of axon extension involved in axon guidance; response to hypoxia; immune response; positive regulation of endothelial cell proliferation; telencephalon cell migration

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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Product References and Citations for SDF-1 recombinant protein

   Arya M., et al. (2007). Tumour Biol. 28(3):123-31.
Kucia M., et al. (2005). Stem Cells. 23(7):879-94.
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 Research Articles on SDF-1    1. The GG genotype of rs1801157 in SDF-1 is an independent risk factor for CHD in Chinese populations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SDF-1 recombinant proteinPathways associated with SDF-1 recombinant protein
 Reference Product  PubMed Publications
 CXCR4 recombinant protein  >3324 publications with SDF-1 and CXCR4
 CCR5 recombinant protein  >295 publications with SDF-1 and CCR5
 CXCR7 recombinant protein  >280 publications with SDF-1 and CXCR7
 CXCR3 recombinant protein  >124 publications with SDF-1 and CXCR3
 HIF1A recombinant protein  >81 publications with SDF-1 and HIF1A
 CCR4 recombinant protein  >42 publications with SDF-1 and CCR4
 STAT3 recombinant protein  >41 publications with SDF-1 and STAT3
 JAK2 recombinant protein  >20 publications with SDF-1 and JAK2
 VAV1 recombinant protein  >17 publications with SDF-1 and VAV1
 SDC4 recombinant protein  >5 publications with SDF-1 and SDC4
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Diseases associated with SDF-1 recombinant proteinOrgans/Tissues associated with SDF-1 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >575 publications with SDF-1 and Cardiovascular Diseases
 Inflammation Antibodies  >568 publications with SDF-1 and Inflammation
 Neoplasm Metastasis Antibodies  >390 publications with SDF-1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >269 publications with SDF-1 and Breast Neoplasms
 Heart Diseases Antibodies  >268 publications with SDF-1 and Heart Diseases
 HIV Infections Antibodies  >262 publications with SDF-1 and HIV Infections
 Ischemia Antibodies  >240 publications with SDF-1 and Ischemia
 Neoplasm Invasiveness Antibodies  >234 publications with SDF-1 and Neoplasm Invasiveness
 Lung Diseases Antibodies  >224 publications with SDF-1 and Lung Diseases
 Necrosis Antibodies  >220 publications with SDF-1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1495 publications with SDF-1 and Bone
 Bone Marrow Antibodies  >1368 publications with SDF-1 and Bone Marrow
 Vascular Antibodies  >1097 publications with SDF-1 and Vascular
 Brain Antibodies  >497 publications with SDF-1 and Brain
 Muscle Antibodies  >368 publications with SDF-1 and Muscle
 Lung Antibodies  >340 publications with SDF-1 and Lung
 Heart Antibodies  >304 publications with SDF-1 and Heart
 Liver Antibodies  >279 publications with SDF-1 and Liver
 Embryonic Tissue Antibodies  >209 publications with SDF-1 and Embryonic Tissue
 Nerve Antibodies  >172 publications with SDF-1 and Nerve
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