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SEPSECS recombinant protein

Scan QR to view Datasheet Catalog #    MBS204016
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SEPSECS, Recombinant Protein

★Popular Item★
 Also Known As   

SEPSECS, 1-501aa, Human, His tag, E Coli

 Product Synonym Names    O-phosphoseryl-tRNA (Sec) selenium transferase; O-phosphoseryl-tRNA (Sec) selenium transferase
 Product Gene Name   

SEPSECS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS204016 COA    COA PDF
 MBS204016 MSDS    MSDS PDF
 Sequence    MGSSHHHHHH SSGLVPRGSH MNRESFAAGE RLVSPAYVRQ GCEARRSHEH LIRLLLEKGK CPENGWDEST LELFLHELAI MDSNNFLGNC GVGEREGRVA SALVARRHYR FIHGIGRSGD ISAVQPKAAG SSLLNKITNS LVLDIIKLAG VHTVANCFVV PMATGMSLTL CFLTLRHKRP KAKYIIWPRI DQKSCFKSMI TAGFEPVVIE NVLEGDELRT DLKAVEAKVQ ELGPDCILCI HSTTSCFAPR VPDRLEELAV ICANYDIPHI VNNAYGVQSS KCMHLIQQGA RVGRIDAFVQ SLDKNFMVPV GGAIIAGFND SFIQEISKMY PGRASASPSL DVLITLLSLG SNGYKKLLKE RKEMFSYLSN QIKKLSEAYN ERLLHTPHNP ISLAMTLKTL DEHRDKAVTQ LGSMLFTRQV SGARVVPLGS MQTVSGYTFR GFMSHTNNYP CAYLNAASAI GMKMQDVDLF IKRLDRCLKA VRKERSKESD DNYDKTEDVD IEEMALKLDN VLLDTYQDAS S
 OMIM    AK292476 mRNA
 3D Structure    ModBase 3D Structure for Q9HD40
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.5) containing 40% glycerol, 0.15M NaCl, 1mM DTT.
 Concentration    0.25mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SEPSECS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SEPSECS recombinant protein

   SEPSECS, also known as SLA/LP autoantigen, catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA (sec) to selenocysteinyl-tRNA (sec) using selenophosphate as the selenium donor. Also, this protein is considered a specific marker of autoimmune hepatitis. Recombinant human SEPSECS protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for SEPSECS recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for SEPSECS recombinant protein   

SDS-PAGE

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 SDS-Page of SEPSECS recombinant protein    SEPSECS recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for SEPSECS. It may not necessarily be applicable to this product.
 NCBI GI #    267844904
 NCBI GeneID    51091
 NCBI Accession #    NP_058651 [Other Products]
 NCBI GenBank Nucleotide #    NM_016955.3 [Other Products]
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 UniProt Primary Accession #    Q9HD40 [Other Products]
 UniProt Secondary Accession #    Q0D2P3; Q17RT1; Q9NXZ5; Q9UGM9; Q9Y353; A8K8W1 [Other Products]
 UniProt Related Accession #    Q9HD40 [Other Products]
 Molecular Weight    57.9kDa (521aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    O-phosphoseryl-tRNA(Sec) selenium transferase
 NCBI Official Synonym Full Names    Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
 NCBI Official Symbol    SEPSECS [Similar Products]
 NCBI Official Synonym Symbols   
LP; SLA; PCH2D; SLA/LP
[Similar Products]
 NCBI Protein Information    O-phosphoseryl-tRNA(Sec) selenium transferase
 UniProt Protein Name    O-phosphoseryl-tRNA(Sec) selenium transferase
 UniProt Synonym Protein Names   
Liver-pancreas antigen; LP; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; Soluble liver antigen; SLA; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein
 Protein Family    O-phosphoseryl-tRNA(Sec) selenium transferase
 UniProt Gene Name    SEPSECS [Similar Products]
 UniProt Synonym Gene Names    TRNP48; LP; Sec synthase; SepSecS; SLA [Similar Products]
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 NCBI Summary for SEPSECS    The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011]
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 UniProt Comments for SEPSECS    Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
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Product References and Citations for SEPSECS recombinant protein

   Palioura S., et al. (2009) Science. 325 (5938):321-5.; Yuan J.,et al. (2006) Proc. Natl. Acad. Sci. u.S.A. 103:18923-18927
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 Research Articles on SEPSECS    1. Epileptic encephalopathy with burst suppression without brain malformations is associated with pathogenic variation in SEPSECS.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SEPSECS recombinant proteinPathways associated with SEPSECS recombinant protein
 Reference Product  PubMed Publications
 PSTK recombinant protein  >8 publications with SEPSECS and PSTK
 SEPHS1 recombinant protein  >2 publications with SEPSECS and SEPHS1
 SEPHS2 recombinant protein  >1 publications with SEPSECS and SEPHS2
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
 Selenoamino Acid Metabolism Pathway antibodies  Selenoamino Acid Metabolism Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram
 Selenocysteine Synthesis Pathway antibodies  Selenocysteine Synthesis Pathway Diagram
Diseases associated with SEPSECS recombinant proteinOrgans/Tissues associated with SEPSECS recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with SEPSECS and Liver Diseases
 PONTOCEREBELLAR HYPOPLASIA, TYPE 2D Antibodies  >2 publications with SEPSECS and PONTOCEREBELLAR HYPOPLASIA, TYPE 2D
 Disease Models, Animal Antibodies  >1 publications with SEPSECS and Disease Models, Animal
 Necrosis Antibodies  >1 publications with SEPSECS and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with SEPSECS and Brain
 Muscle Antibodies  >4 publications with SEPSECS and Muscle
 Liver Antibodies  >2 publications with SEPSECS and Liver
 Blood Antibodies  >2 publications with SEPSECS and Blood
 Skin Antibodies  >1 publications with SEPSECS and Skin
 Placenta Antibodies  >1 publications with SEPSECS and Placenta
 Bone Antibodies  >1 publications with SEPSECS and Bone
 Embryonic Tissue Antibodies  >1 publications with SEPSECS and Embryonic Tissue
 Kidney Antibodies  >1 publications with SEPSECS and Kidney
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