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SERPINH1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS8249780 SERPINH1 recombinant protein
Unit / Price
0.01 mg  /  $255 +1 FREE 8GB USB
0.05 mg  /  $635 +1 FREE 8GB USB
0.5 mg  /  $2,370 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SERPINH1, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human SERPINH1 Protein

 Product Synonym Names    CBP1; CBP2; HSP47; SERPINH2; Serpin H1; 47 kDa heat shock protein; Arsenic-transactivated protein 3; AsTP3; Cell proliferation-inducing gene 14 protein; Collagen-binding protein; Colligin; Rheumatoid arthritis-related antigen RA-A47
 Product Gene Name   

SERPINH1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    AEVKKPAAAA APGTAEKLSP KAATLAERSA GLAFSLYQAM AKDQAVENIL VSPVVVASSL GLVSLGGKAT TASQAKAVLS AEQLRDEEVH AGLGELLRSL SNSTARNVTW KLGSRLYGPS SVSFADDFVR SSKQHYNCEH SKINFRDKRS ALQSINEWAA QTTDGKLPEV TKDVERTDGA LLVNAMFFKP HWDEKFHHKM VDNRGFMVTR SYTVGVMMMH RTGLYNYYDD EKEKLQIVEM PLAHKLSSLI ILMPHHVEPL ERLEKLLTKE QLKIWMGKMQ KKAVAISLPK GVVEVTHDLQ KHLAGLGLTE AIDKNKADLS RMSGKKDLYL ASVFHATAFE LDTDGNPFDQ DIYGREELRS PKLFYADHPF IFLVRDTQSG SLLFIGRLVR PKGDKMRDEL VDHHHHHH
 OMIM    X61598 mRNA
 3D Structure    ModBase 3D Structure for P50454
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 Species Reactivity    Human
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 Purity/Purification    Greater than 95% as determined by reducing SDS-PAGE.
 Form/Format    Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
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 Source    Human cells
 Endotoxin    Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
 Directions for Use    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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 Preparation and Storage    Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.
 Other Notes    Small volumes of SERPINH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SERPINH1 recombinant protein

   Recombinant Human SERPINH1 Protein is produced by our Mammalian expression system and the target gene encoding Ala19-Leu418 is expressed with a 6His tag at the C-terminus.
 Applications Tested/Suitable for SERPINH1 recombinant protein   

ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

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NCBI/Uniprot data below describe general gene information for SERPINH1. It may not necessarily be applicable to this product.
 NCBI GI #    333360851
 NCBI GeneID    871
 NCBI Accession #    NP_001193943.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001207014.1 [Other Products]
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 UniProt Primary Accession #    P50454 [Other Products]
 UniProt Secondary Accession #    P29043; Q5XPB4; Q6NSJ6; Q8IY96; Q9NP88; B3KVJ3 [Other Products]
 UniProt Related Accession #    P50454 [Other Products]
 Molecular Weight    46,441 Da
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 NCBI Official Full Name    serpin H1
 NCBI Official Synonym Full Names    serpin family H member 1
 NCBI Official Symbol    SERPINH1 [Similar Products]
 NCBI Official Synonym Symbols   
CBP1; CBP2; OI10; gp46; AsTP3; HSP47; PIG14; PPROM; RA-A47; SERPINH2
[Similar Products]
 NCBI Protein Information    serpin H1
 UniProt Protein Name    Serpin H1
 UniProt Synonym Protein Names   
47 kDa heat shock protein; Arsenic-transactivated protein 3; AsTP3; Cell proliferation-inducing gene 14 protein; Collagen-binding protein; Colligin; Rheumatoid arthritis-related antigen RA-A47
 Protein Family    Serpin
 UniProt Gene Name    SERPINH1 [Similar Products]
 UniProt Synonym Gene Names    CBP1; CBP2; HSP47; SERPINH2; AsTP3; Colligin [Similar Products]
 UniProt Entry Name    SERPH_HUMAN
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 NCBI Summary for SERPINH1    This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
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 UniProt Comments for SERPINH1    SERPINH1: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. Defects in SERPINH1 are the cause of osteogenesis imperfecta type 10 (OI10). A connective tissue disorder characterized by bone fragility, low bone mass, bowing of limbs due to multiple fractures, short limb dwarfism and blue sclerae. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; ER-Golgi intermediate compartment; extracellular space; lipid raft

Molecular Function: collagen binding

Biological Process: collagen fibril organization; response to unfolded protein

Disease: Osteogenesis Imperfecta, Type X; Preterm Premature Rupture Of The Membranes
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 Research Articles on SERPINH1    1. The present study demonstrates that HSP47 promotes glioma angiogenesis and highlights the importance of HSP47 as an attractive therapeutic target of GBM.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SERPINH1 recombinant proteinPathways associated with SERPINH1 recombinant protein
 Reference Product  PubMed Publications
 CRTAP recombinant protein  >11 publications with SERPINH1 and CRTAP
 LEPRE1 recombinant protein  >11 publications with SERPINH1 and LEPRE1
 PPIB recombinant protein  >9 publications with SERPINH1 and PPIB
 HSPB1 recombinant protein  >6 publications with SERPINH1 and HSPB1
 HSPA8 recombinant protein  >2 publications with SERPINH1 and HSPA8
 DNAJB1 recombinant protein  >1 publications with SERPINH1 and DNAJB1
 HSPH1 recombinant protein  >1 publications with SERPINH1 and HSPH1
 UBC recombinant protein  >1 publications with SERPINH1 and UBC
 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with SERPINH1 recombinant proteinOrgans/Tissues associated with SERPINH1 recombinant protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >83 publications with SERPINH1 and Fibrosis
 Kidney Diseases Antibodies  >29 publications with SERPINH1 and Kidney Diseases
 Disease Models, Animal Antibodies  >28 publications with SERPINH1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >19 publications with SERPINH1 and Cardiovascular Diseases
 Inflammation Antibodies  >17 publications with SERPINH1 and Inflammation
 Liver Diseases Antibodies  >12 publications with SERPINH1 and Liver Diseases
 Necrosis Antibodies  >11 publications with SERPINH1 and Necrosis
 Liver Cirrhosis Antibodies  >9 publications with SERPINH1 and Liver Cirrhosis
 Neoplasms, Experimental Antibodies  >7 publications with SERPINH1 and Neoplasms, Experimental
 Heart Diseases Antibodies  >7 publications with SERPINH1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >56 publications with SERPINH1 and Muscle
 Kidney Antibodies  >40 publications with SERPINH1 and Kidney
 Blood Antibodies  >33 publications with SERPINH1 and Blood
 Bone Antibodies  >32 publications with SERPINH1 and Bone
 Connective Tissue Antibodies  >32 publications with SERPINH1 and Connective Tissue
 Vascular Antibodies  >28 publications with SERPINH1 and Vascular
 Skin Antibodies  >27 publications with SERPINH1 and Skin
 Liver Antibodies  >24 publications with SERPINH1 and Liver
 Lung Antibodies  >23 publications with SERPINH1 and Lung
 Embryonic Tissue Antibodies  >15 publications with SERPINH1 and Embryonic Tissue
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