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FRZB recombinant protein :: SFRP3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS637291 FRZB recombinant protein
Unit / Price
0.01 mg  /  $710 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SFRP3 (FRZB), Recombinant Protein

★Popular Item★
 Also Known As   

SFRP3, Recombinant, Mouse (Secreted Frizzled Related Protein 3, FRZB, Fritz, Frzb1)

 Product Gene Name   

FRZB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (183698002..183731498, complement). Location: 2q32.1
 OMIM    165720
 3D Structure    ModBase 3D Structure for Q92765
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 Purity/Purification    Highly Purified
=>95%, as determined by SDS-PAGE and visualized by silver stain.
 Form/Format    Supplied as a lyophilized powder in PBS, pH 7.4, BSA. Reconstitute with 100 uL sterile PBS.
 Concentration    ~0.1 mg/mL(after reconstitution) (lot specific)
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 Source    A DNA sequence encoding the mature mouse sFRP-3 protein sequence Ala33-Ser323 was fused to a 6X histidine tag at the carboxy-terminus. The fusion protein was expressed in a mouse myeloma cell line, NS0. Swiss/UniProt Accession: P97401
 Molecular Mass    Based on N-terminal sequencing, the mature mouse sFRP-3 protein starts at Ala33 and has a calculated molecular mass of 34kD. As a result of glycosylation, the recombinant protein migrates as an ~37kD protein in SDS-PAGE under reducing conditions.
 Activity    Measured by its ability to inhibit proliferation in MC3T3-E1 mouse preosteoblast cells. ED501.5-6.0 ug/mL.
 Endotoxin    <1.0 EU per 1 ug (LAL)
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 Preparation and Storage    Lyophilized powder may be stored at -20C.Stable for 6 months after receipt at -20C.Reconstitute with sterile PBS.Aliquot to avoid repeated freezing and thawing. Store at -70C.For maximum recovery of procut, centrifuge the original vial after thawing and prior to removing the cap.

Shipping: Ships with dry ice
 Other Notes    Small volumes of FRZB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for FRZB recombinant protein

   Secreted Frizzled Related Protein 3 (sFRP-3) was originally identified in bovine cartilage for its chondrogenic ability. Human, mouse, chick and Xenopus clones have also been isolated. sFRP-3 is often referred to as FRZB, other names also include Fritz, Frzb1, and FRP-3. At the amino acid sequence level, sFRP-3 is highly conserved. The mouse protein shares 76% identity with Xenopus, and 92% with human proteins. The gene for mouse sFRP-3 has been localized to the central region of chromosome 2. Murine sFRP-3 is expressed in the primitive streak during gastrulation, as well as in the retina, foregut diverticulum, nervous system, and posterior mesoderm during development. In adult tissues, sFRP-3 expression, as determined by Northern blot, is detected in the heart, brain, spleen, skeletal muscle, kidney and testis. The N-terminal portion of sFRP-3 protein shows 50% amino acid identity to the corresponding region of the Drosophila frizzled gene product, a receptor for Wg/Wnt signals. The similarity of sFRP-3 with frizzled proteins is restricted to the N-terminal cysteine-rich domain (CRD) that contains at least ten cysteine residues with highly conserved spacing between them. sFRP-3 was subsequently shown to be a soluble antagonist of Wnt signals. It lacks all transmembrane domains of frizzled proteins but retains the ability to bind Wnts. Ectopic expression of sFRP-3 mRNA has been shown to interfere with the induction of secondary axes in Xenopus embryos injected with Xwnt-8 mRNA (Hoang et al., 1996, J. Biol. Chem. 271:26131; Leyns et al., 1997, Cell 88:747;
 Product Categories/Family for FRZB recombinant protein    Molecular Biology; MB-Wnt Proteins
NCBI/Uniprot data below describe general gene information for FRZB. It may not necessarily be applicable to this product.
 NCBI GI #    38455388
 NCBI GeneID    2487
 NCBI Accession #    NP_001454.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001463.3 [Other Products]
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 UniProt Primary Accession #    Q92765 [Other Products]
 UniProt Secondary Accession #    O00181; Q99686 [Other Products]
 UniProt Related Accession #    Q92765 [Other Products]
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 NCBI Official Full Name    secreted frizzled-related protein 3
 NCBI Official Synonym Full Names    frizzled-related protein
 NCBI Official Symbol    FRZB [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    secreted frizzled-related protein 3; sFRP-3; frezzled; frizzled homolog-related; frizzled-related protein 1
 UniProt Protein Name    Secreted frizzled-related protein 3
 UniProt Synonym Protein Names   
Frezzled; Fritz; Frizzled-related protein 1; FrzB-1
 Protein Family    Secreted frizzled-related protein
 UniProt Gene Name    FRZB [Similar Products]
 UniProt Synonym Gene Names    FIZ; FRE; FRP; FRZB1; SFRP3; sFRP-3 [Similar Products]
 UniProt Entry Name    SFRP3_HUMAN
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 NCBI Summary for FRZB    The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
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 UniProt Comments for FRZB    FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: extracellular space; membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity

Biological Process: negative regulation of cell proliferation; convergent extension involved in organogenesis; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; positive regulation of fat cell differentiation; neural crest cell differentiation; negative regulation of cell growth; skeletal development

Disease: Osteoarthritis Susceptibility 1
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 Research Articles on FRZB    1. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FRZB recombinant proteinPathways associated with FRZB recombinant protein
 Reference Product  PubMed Publications
 ASPN recombinant protein  >6 publications with FRZB and ASPN
 SMOC2 recombinant protein  >2 publications with FRZB and SMOC2
 MATN3 recombinant protein  >1 publications with FRZB and MATN3
 MYOD1 recombinant protein  >1 publications with FRZB and MYOD1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with FRZB recombinant proteinOrgans/Tissues associated with FRZB recombinant protein
 Disease Name  Pubmed Publications
 Osteoarthritis Antibodies  >41 publications with FRZB and Osteoarthritis
 Neoplasms Antibodies  >40 publications with FRZB and Neoplasms
 Disease Models, Animal Antibodies  >12 publications with FRZB and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >8 publications with FRZB and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >6 publications with FRZB and Adenocarcinoma
 Breast Neoplasms Antibodies  >6 publications with FRZB and Breast Neoplasms
 Kidney Diseases Antibodies  >5 publications with FRZB and Kidney Diseases
 Brain Diseases Antibodies  >5 publications with FRZB and Brain Diseases
 Kidney Neoplasms Antibodies  >5 publications with FRZB and Kidney Neoplasms
 Inflammation Antibodies  >4 publications with FRZB and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >74 publications with FRZB and Bone
 Embryonic Tissue Antibodies  >40 publications with FRZB and Embryonic Tissue
 Muscle Antibodies  >23 publications with FRZB and Muscle
 Connective Tissue Antibodies  >17 publications with FRZB and Connective Tissue
 Eye Antibodies  >14 publications with FRZB and Eye
 Brain Antibodies  >12 publications with FRZB and Brain
 Kidney Antibodies  >11 publications with FRZB and Kidney
 Liver Antibodies  >10 publications with FRZB and Liver
 Bone Marrow Antibodies  >9 publications with FRZB and Bone Marrow
 Heart Antibodies  >9 publications with FRZB and Heart
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