Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow SH2D1A  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • dehydrogenase-reductase (SDR family) member 2 (DHRS2) ELISA Kit
 • NFKBIA Antibody
 • FOXRED1 siRNA
 • CD80 Antibody
 • HBB Antibody
 • A disintegrin and metalloproteinase with thrombospondin moti... ELISA Kit
 • Anti-glucoprotein 210, GP210 ELISA Kit
 • GAS6 Antibody
 • EZBlock Universal Protease and Phosphatase Inhibitor Cocktai... Biochemical
 • Peroxiredoxin-1 (PRDX1) Recombinant Protein
 • 7-alpha-hydroxycholest-4-en -3-one 12-alpha-hydroxylase (CYP8... ELISA Kit
 • IL4 Antibody
 • Crm, cramped-like (Drosophila) (CRAMP1L) ELISA Kit
 • Disintegrin and metalloproteinase domain-containing protein ... Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SH2D1A recombinant protein

Scan QR to view Datasheet Catalog #    MBS203869
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SH2D1A, Recombinant Protein

★Popular Item★
 Also Known As   

SH2D1A, 1-128aa, Human, His tag, E Coli

 Product Synonym Names    SH2 domain-containing protein 1A; DSHP; EBVS; IMD5; LYP; MTCP1; SAP; XLP; XLPD
 Product Gene Name   

SH2D1A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP
 OMIM    AL023657 mRNA
 3D Structure    ModBase 3D Structure for O60880
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 1 mM DTT, 10% glycerol
 Concentration    1mg/ml (determined by Bradford assay) (lot specific)
Section Bar
 Antigen Species    Human
 Tag Information    His-tag
Section Bar
 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SH2D1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for SH2D1A recombinant protein

   SH2D1A is an inhibitor of the signaling lymphocyte activation molecule (SLAM) self-association. This protein is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD) also known as Duncan disease. XLPD is characterized by a rare congenital immunodeficiency following Epstein-Barr virus (EBV) infection. Recombinant human SH2D1A protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for SH2D1A recombinant protein    Immunology
 Applications Tested/Suitable for SH2D1A recombinant protein   

SDS-PAGE

Section Bar
 SDS-Page of SH2D1A recombinant protein    SH2D1A recombinant protein SDS-Page image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SH2D1A. It may not necessarily be applicable to this product.
 NCBI GI #    4506923
 NCBI GeneID    4068
 NCBI Accession #    NP_002342 [Other Products]
 NCBI GenBank Nucleotide #    NM_002351.4 [Other Products]
Section Bar
 UniProt Primary Accession #    O60880 [Other Products]
 UniProt Secondary Accession #    O95383; O95384; O95385; O95386; Q6FGS6; Q9UNR0; A8MSW0 [Other Products]
 UniProt Related Accession #    O60880 [Other Products]
 Molecular Weight    16.3 kDa (148aa), confirmed by MALDI-TOF
Table BarTOPTable Bar
 NCBI Official Full Name    SH2 domain-containing protein 1A isoform 1
 NCBI Official Synonym Full Names    SH2 domain containing 1A
 NCBI Official Symbol    SH2D1A [Similar Products]
 NCBI Official Synonym Symbols   
LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A
[Similar Products]
 NCBI Protein Information    SH2 domain-containing protein 1A
 UniProt Protein Name    SH2 domain-containing protein 1A
 UniProt Synonym Protein Names   
Duncan disease SH2-protein; Signaling lymphocytic activation molecule-associated protein; SLAM-associated protein; T-cell signal transduction molecule SAP
 Protein Family    SH2 domain-containing protein
 UniProt Gene Name    SH2D1A [Similar Products]
 UniProt Synonym Gene Names    DSHP; SAP; SLAM-associated protein [Similar Products]
Section Bar
 NCBI Summary for SH2D1A    This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for SH2D1A    Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Table BarTOPTable Bar
 

Product References and Citations for SH2D1A recombinant protein

   Schwartzberg PL., et al. (2010) Immunity. 32 (2):253-65.; Lenardo MJ., et al (2009) J Clin Invest. 119 (10):2976-89;
Section Bar
 Research Articles on SH2D1A    1. we describe for the first time the clinical manifestations associated with XLP-1 based on the c.278G>A variant in the SH2D1A gene. The patient had a relatively late age of onset and presented mainly with primary HLH associated with EBV infection without a familial history of immunodeficiency.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with SH2D1A recombinant proteinPathways associated with SH2D1A recombinant protein
 Reference Product  PubMed Publications
 SRC recombinant protein  >99 publications with SH2D1A and SRC
 CD244 recombinant protein  >51 publications with SH2D1A and CD244
 FYN recombinant protein  >39 publications with SH2D1A and FYN
 SLAMF1 recombinant protein  >22 publications with SH2D1A and SLAMF1
 LY9 recombinant protein  >16 publications with SH2D1A and LY9
 SLAMF6 recombinant protein  >15 publications with SH2D1A and SLAMF6
 LCK recombinant protein  >8 publications with SH2D1A and LCK
 SLAMF7 recombinant protein  >5 publications with SH2D1A and SLAMF7
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Diseases associated with SH2D1A recombinant proteinOrgans/Tissues associated with SH2D1A recombinant protein
 Disease Name  Pubmed Publications
 Lymphoproliferative Disorders Antibodies  >205 publications with SH2D1A and Lymphoproliferative Disorders
 Nervous System Diseases Antibodies  >16 publications with SH2D1A and Nervous System Diseases
 Necrosis Antibodies  >8 publications with SH2D1A and Necrosis
 Inflammation Antibodies  >8 publications with SH2D1A and Inflammation
 Vascular Diseases Antibodies  >7 publications with SH2D1A and Vascular Diseases
 Cardiovascular Diseases Antibodies  >7 publications with SH2D1A and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with SH2D1A and Cell Transformation, Neoplastic
 Pneumonia Antibodies  >3 publications with SH2D1A and Pneumonia
 Metabolic Diseases Antibodies  >3 publications with SH2D1A and Metabolic Diseases
 Blood Coagulation Disorders Antibodies  >2 publications with SH2D1A and Blood Coagulation Disorders
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >266 publications with SH2D1A and Blood
 Bone Marrow Antibodies  >28 publications with SH2D1A and Bone Marrow
 Thymus Antibodies  >14 publications with SH2D1A and Thymus
 Liver Antibodies  >8 publications with SH2D1A and Liver
 Spleen Antibodies  >8 publications with SH2D1A and Spleen
 Lung Antibodies  >4 publications with SH2D1A and Lung
 Prostate Antibodies  >2 publications with SH2D1A and Prostate
 Pharynx Antibodies  >2 publications with SH2D1A and Pharynx
 Testis Antibodies  >1 publications with SH2D1A and Testis
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions