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SIRT6 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203202
SDS-Page
Unit / Price
0.1 mg  /  $510 +1 FREE 8GB USB
0.5 mg  /  $1,335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIRT6, Recombinant Protein

★Popular Item★
 Also Known As   

SIRT6, 1-355aa,Human, His tag, E Coli

 Product Synonym Names    Sirtuin 6; SIR2L6; Mono-ADP-ribosyltransferase sirtuin-6; SIR2-like protein 6; Sirtuin 6 Mono ADP ribosyltransferase sirtuin 6; SIR2 like protein 6; Sir2 related protein type 6; SIRT 6; Sirtuin (silent mating type information regulation 2 homolog) 6 (S; cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6.
 Product Gene Name   

SIRT6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS
 OMIM    AF233396 mRNA
 3D Structure    ModBase 3D Structure for Q8N6T7
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 7.5) containing 20% glycerol, 1mM DTT, 0.1M NaCl, 0.1mM PMSF
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SIRT6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SIRT6 recombinant protein

   The SIRT6 is included in class IV of the sirtuin family, homologs to the yeast Sir2 protein. The functions of human sirtuins have not yet been determined; however, in yeast sirtuins are known to regulate epigenetic gene silencing. Also SIRT6, a chromatin-associated protein, appears to be involved in DNA repair. Recombinant SIRT6, fused to His-tag at N-terminus, was expressed in E Coli and purified by conventional chromatography techniques.
 Product Categories/Family for SIRT6 recombinant protein    Cell Cycle
 Applications Tested/Suitable for SIRT6 recombinant protein   

SDS-PAGE

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 SDS-Page of SIRT6 recombinant protein    SIRT6 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for SIRT6. It may not necessarily be applicable to this product.
 NCBI GI #    300797577
 NCBI GeneID    51548
 NCBI Accession #    NP_057623 [Other Products]
 NCBI GenBank Nucleotide #    NM_016539.3 [Other Products]
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 UniProt Primary Accession #    Q8N6T7 [Other Products]
 UniProt Secondary Accession #    O75291; Q6IAF5; Q6PK99; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1; B2RCD0 [Other Products]
 UniProt Related Accession #    Q8N6T7 [Other Products]
 Molecular Weight    41 kDa (375 aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    NAD-dependent protein deacetylase sirtuin-6 isoform 1
 NCBI Official Synonym Full Names    sirtuin 6
 NCBI Official Symbol    SIRT6 [Similar Products]
 NCBI Official Synonym Symbols   
SIR2L6
[Similar Products]
 NCBI Protein Information    NAD-dependent protein deacetylase sirtuin-6
 UniProt Protein Name    NAD-dependent protein deacetylase sirtuin-6
 UniProt Synonym Protein Names   
Regulatory protein SIR2 homolog 6; SIR2-like protein 6
 Protein Family    NAD-dependent protein deacetylase
 UniProt Gene Name    SIRT6 [Similar Products]
 UniProt Synonym Gene Names    SIR2L6 [Similar Products]
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 NCBI Summary for SIRT6    This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
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 UniProt Comments for SIRT6    NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.
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Product References and Citations for SIRT6 recombinant protein

   Michishita E., et al. (2008) Nature. 452 (7186):492-6.; Mostoslavsky R., et al. (2006) Cell. 124 (2):315-29.;
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 Research Articles on SIRT6    1. in vitro and in vivo studies showed that gene silencing of SIRT6 suppressed cell proliferation and promoted cellular apoptosis by activating the Bax-dependent apoptotic signal pathway in Hepatocellular Carcinoma cells. Furthermore, SIRT6 knockdown could increase liver cancer cell sensitivity to chemotherapy drug doxorubicin. SIRT6 is an important protumorigenic factor in liver carcinogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SIRT6 recombinant proteinPathways associated with SIRT6 recombinant protein
 Reference Product  PubMed Publications
 FOXO1 recombinant protein  >12 publications with SIRT6 and FOXO1
 MYC recombinant protein  >11 publications with SIRT6 and MYC
 HIF1A recombinant protein  >8 publications with SIRT6 and HIF1A
 HDAC1 recombinant protein  >4 publications with SIRT6 and HDAC1
 AKT1 recombinant protein  >4 publications with SIRT6 and AKT1
 HDAC3 recombinant protein  >2 publications with SIRT6 and HDAC3
 HDAC9 recombinant protein  >2 publications with SIRT6 and HDAC9
 HDAC2 recombinant protein  >2 publications with SIRT6 and HDAC2
 RBBP8 recombinant protein  >2 publications with SIRT6 and RBBP8
 PRKDC recombinant protein  >1 publications with SIRT6 and PRKDC
 Products by Pathway  Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway antibodies  HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway Diagram
 Homology Directed Repair Pathway antibodies  Homology Directed Repair Pathway Diagram
 NAD+ Biosynthetic Pathways antibodies  NAD+ Biosynthetic Pathways Diagram
 NAD+ Metabolism Pathway antibodies  NAD+ Metabolism Pathway Diagram
 Processing Of DNA Double-strand Break Ends Pathway antibodies  Processing Of DNA Double-strand Break Ends Pathway Diagram
 SREBF And MiR33 In Cholesterol And Lipid Homeostasis Pathway antibodies  SREBF And MiR33 In Cholesterol And Lipid Homeostasis Pathway Diagram
Diseases associated with SIRT6 recombinant proteinOrgans/Tissues associated with SIRT6 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >75 publications with SIRT6 and Inflammation
 Cardiovascular Diseases Antibodies  >51 publications with SIRT6 and Cardiovascular Diseases
 Necrosis Antibodies  >22 publications with SIRT6 and Necrosis
 Hypertrophy Antibodies  >21 publications with SIRT6 and Hypertrophy
 Disease Models, Animal Antibodies  >19 publications with SIRT6 and Disease Models, Animal
 Atherosclerosis Antibodies  >16 publications with SIRT6 and Atherosclerosis
 Carcinoma, Hepatocellular Antibodies  >16 publications with SIRT6 and Carcinoma, Hepatocellular
 Fatty Liver Antibodies  >14 publications with SIRT6 and Fatty Liver
 Fibrosis Antibodies  >14 publications with SIRT6 and Fibrosis
 Liver Neoplasms Antibodies  >13 publications with SIRT6 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >53 publications with SIRT6 and Liver
 Muscle Antibodies  >42 publications with SIRT6 and Muscle
 Brain Antibodies  >42 publications with SIRT6 and Brain
 Blood Antibodies  >40 publications with SIRT6 and Blood
 Heart Antibodies  >39 publications with SIRT6 and Heart
 Bone Antibodies  >27 publications with SIRT6 and Bone
 Lung Antibodies  >26 publications with SIRT6 and Lung
 Skin Antibodies  >16 publications with SIRT6 and Skin
 Connective Tissue Antibodies  >13 publications with SIRT6 and Connective Tissue
 Kidney Antibodies  >12 publications with SIRT6 and Kidney
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