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SMAC recombinant protein :: SMAC/Diablo Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203157
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SMAC/Diablo, Recombinant Protein

 Also Known As   

SMAC/Diablo, 56-239aa, Human, T7 tag, E Coli

 Product Synonym Names    Diablo isoform 1; SMAC3; DIABLO-S; FLJ10537; FLJ25049; Diablo isoform 1; SMAC/Diablo; Diablo isoform 1 0610041G12Rik; DBOH; Diablo homolog; DIABLO S; Diablo homolog (Drosophila); Mitochondrial Smac protein; Diablo homolog mitochondrial; SMAC 3; Smac protein; Direct IAP binding protein with low pI; Second mitochondria derived activator of caspase.
 Product Gene Name   

SMAC recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MASMTGGQQM GRGSMAVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED
 OMIM    AF262240 mRNA
 3D Structure    ModBase 3D Structure for Q9NR28
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid in 20mM Tris pH 7.5
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    T7 tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SMAC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SMAC recombinant protein

   Smac/Diablo is one of the proapoptotic proteins. Smac promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. Recombinant human Smac fused to T7-tag. at N-terminus was expressed in E Coli and purified by conventional chromatography techniques.
 Product Categories/Family for SMAC recombinant protein    Cancer
 Applications Tested/Suitable for SMAC recombinant protein   

SDS-PAGE

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 SDS-Page of SMAC recombinant protein    SMAC recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for SMAC. It may not necessarily be applicable to this product.
 NCBI GI #    9845297
 NCBI GeneID    56616
 NCBI Accession #    NP_063940 [Other Products]
 NCBI GenBank Nucleotide #    NM_019887.5 [Other Products]
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 UniProt Primary Accession #    Q9NR28 [Other Products]
 UniProt Secondary Accession #    Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; B2RDQ0 [Other Products]
 UniProt Related Accession #    Q9NR28 [Other Products]
 Molecular Weight    22 kDa (199 aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    diablo homolog, mitochondrial isoform 1
 NCBI Official Synonym Full Names    diablo IAP-binding mitochondrial protein
 NCBI Official Symbol    DIABLO [Similar Products]
 NCBI Official Synonym Symbols   
SMAC; DFNA64
[Similar Products]
 NCBI Protein Information    diablo homolog, mitochondrial
 UniProt Protein Name    Diablo homolog, mitochondrial
 UniProt Synonym Protein Names   
Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac
 UniProt Gene Name    DIABLO [Similar Products]
 UniProt Synonym Gene Names    SMAC; Smac [Similar Products]
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 NCBI Summary for SMAC    This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
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 UniProt Comments for SMAC    Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
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Product References and Citations for SMAC recombinant protein

   Srinivasula SM., et al. (2000). J Biol Chem. 275 (46):36152-7.; Du C., et al. (2000). Cell. 102 (1):33-42.;
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 Research Articles on SMAC    1. analysis of Smac-mediated apoptosis in chronic lymphocytic leukemia cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SMAC recombinant proteinPathways associated with SMAC recombinant protein
 Reference Product  PubMed Publications
 CASP3 recombinant protein  >395 publications with SMAC and CASP3
 XIAP recombinant protein  >342 publications with SMAC and XIAP
 BAX recombinant protein  >248 publications with SMAC and BAX
 CASP9 recombinant protein  >93 publications with SMAC and CASP9
 BCL2L1 recombinant protein  >72 publications with SMAC and BCL2L1
 APAF1 recombinant protein  >32 publications with SMAC and APAF1
 BCL2 recombinant protein  >29 publications with SMAC and BCL2
 BIRC2 recombinant protein  >27 publications with SMAC and BIRC2
 BIRC3 recombinant protein  >23 publications with SMAC and BIRC3
 BAK1 recombinant protein  >20 publications with SMAC and BAK1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptotic Factor-mediated Response Pathway antibodies  Apoptotic Factor-mediated Response Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Intrinsic Pathway For Apoptosis antibodies  Intrinsic Pathway For Apoptosis Diagram
Diseases associated with SMAC recombinant proteinOrgans/Tissues associated with SMAC recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >201 publications with SMAC and Necrosis
 Leukemia Antibodies  >124 publications with SMAC and Leukemia
 Neoplasms, Experimental Antibodies  >47 publications with SMAC and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >47 publications with SMAC and Lung Neoplasms
 Liver Diseases Antibodies  >44 publications with SMAC and Liver Diseases
 Breast Neoplasms Antibodies  >42 publications with SMAC and Breast Neoplasms
 Disease Models, Animal Antibodies  >40 publications with SMAC and Disease Models, Animal
 Liver Neoplasms Antibodies  >35 publications with SMAC and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >33 publications with SMAC and Carcinoma, Hepatocellular
 Inflammation Antibodies  >31 publications with SMAC and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >126 publications with SMAC and Blood
 Brain Antibodies  >104 publications with SMAC and Brain
 Liver Antibodies  >77 publications with SMAC and Liver
 Lung Antibodies  >66 publications with SMAC and Lung
 Muscle Antibodies  >49 publications with SMAC and Muscle
 Prostate Antibodies  >39 publications with SMAC and Prostate
 Heart Antibodies  >39 publications with SMAC and Heart
 Kidney Antibodies  >39 publications with SMAC and Kidney
 Nerve Antibodies  >31 publications with SMAC and Nerve
 Vascular Antibodies  >26 publications with SMAC and Vascular
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