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SNAPIN recombinant protein :: SNAP Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143532 SNAPIN recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SNAP (SNAPIN), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human SNAP Associated Protein

 Product Synonym Names    SNAPIN Human; SNAP Associated Protein Human Recombinant; SNAPAP; SNARE-associated protein Snapin; Synaptosomal-associated protein 25-binding protein; SNAP-associated protein; SNAPIN; SNAP25BP
 Product Gene Name   

SNAPIN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MAGAGS AAVS GAGTPVAGPT GRDLFAEGLL EFLRPAVQQL DSHVHAVRES QVELREQIDN LATELCRINE DQKVALDLDP YVKKLLNARR RVVLVNNILQ NAQERLRRLN HSVAKETARR RAMLDSGIYP PGSPGK
 OMIM    607007
 3D Structure    ModBase 3D Structure for O95295
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The protein solution contains 20mM Tris-HCl pH-8, 5mM DTT, 2mM EDTA, 0.2M NaCl, and 40% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of SNAPIN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SNAPIN recombinant protein

   Description: SNAPIN Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (1-136) and having a molecular mass of 17 kDa. SNAPIN is fused to 20 amino acid His Tag at N-terminus and purified by standard chromatography techniques.

Introduction: SNAPIN is involved in the neurotransmitter release process through its modulation of the sequential interactions between the SNAREs and synaptotagmin. SNAPIN is part of the SNARE complex of proteins that is needed for synaptic vesicle docking and fusion. SNAPAP is enriched in neurons and exclusively located on synaptic vesicle membrane protein. SNAPIN is also an important factor of the BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.
 Product Categories/Family for SNAPIN recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Synaptosomal Associated Protein
NCBI/Uniprot data below describe general gene information for SNAPIN. It may not necessarily be applicable to this product.
 NCBI GI #    6912674
 NCBI GeneID    23557
 NCBI Accession #    NP_036569.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012437.5 [Other Products]
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 UniProt Primary Accession #    O95295 [Other Products]
 UniProt Secondary Accession #    Q5SXU8; D3DV56 [Other Products]
 UniProt Related Accession #    O95295 [Other Products]
 Molecular Weight    14,874 Da
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 NCBI Official Full Name    SNARE-associated protein Snapin
 NCBI Official Synonym Full Names    SNAP-associated protein
 NCBI Official Symbol    SNAPIN [Similar Products]
 NCBI Official Synonym Symbols   
BLOS7; SNAPAP; BLOC1S7
[Similar Products]
 NCBI Protein Information    SNARE-associated protein Snapin; BLOC-1 subunit 7; SNAP-25-binding protein; SNARE associated protein snapin; biogenesis of lysosomal organelles complex-1, subunit 7; biogenesis of lysosome-related organelles complex 1 subunit 7; synaptosomal-associated protein 25-binding protein
 UniProt Protein Name    SNARE-associated protein Snapin
 UniProt Synonym Protein Names   
Biogenesis of lysosome-related organelles complex 1 subunit 7; BLOC-1 subunit 7; Synaptosomal-associated protein 25-binding protein; SNAP-associated protein
 Protein Family    SNAPIN protein
 UniProt Gene Name    SNAPIN [Similar Products]
 UniProt Synonym Gene Names    BLOC1S7; SNAP25BP; SNAPAP; BLOC-1 subunit 7; SNAP-associated protein [Similar Products]
 UniProt Entry Name    SNAPN_HUMAN
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 NCBI Summary for SNAPIN    The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
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 UniProt Comments for SNAPIN    SNAPIN: a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. Phosphorylation by PKA modulates its interaction with the SNARE complex.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: Golgi membrane; Golgi apparatus; synaptic vesicle; transport vesicle; cytoplasmic vesicle membrane; synaptic vesicle membrane; perinuclear region of cytoplasm; nucleolus; synapse; cell junction; secretory granule

Molecular Function: SNARE binding; protein binding

Biological Process: viral reproduction; synaptic vesicle maturation; neurotransmitter secretion; synaptic vesicle transport; synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; synaptic vesicle exocytosis; melanosome organization and biogenesis; regulation of protein binding; anterograde synaptic vesicle transport; endosome to lysosome transport; anterograde axon cargo transport; neurite development
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 Research Articles on SNAPIN    1. Authors propose that Snapin connects chlamydial inclusions with the microtubule network by interacting with both Chlamydia psittaci IncB and dynein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SNAPIN recombinant proteinPathways associated with SNAPIN recombinant protein
 Reference Product  PubMed Publications
 SNAP25 recombinant protein  >18 publications with SNAPIN and SNAP25
 DTNBP1 recombinant protein  >5 publications with SNAPIN and DTNBP1
 MUTED recombinant protein  >4 publications with SNAPIN and MUTED
 TMEM27 recombinant protein  >3 publications with SNAPIN and TMEM27
 BLOC1S1 recombinant protein  >3 publications with SNAPIN and BLOC1S1
 EBAG9 recombinant protein  >2 publications with SNAPIN and EBAG9
 PLDN recombinant protein  >2 publications with SNAPIN and PLDN
 BLOC1S3 recombinant protein  >1 publications with SNAPIN and BLOC1S3
 BLOC1S2 recombinant protein  >1 publications with SNAPIN and BLOC1S2
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
Diseases associated with SNAPIN recombinant proteinOrgans/Tissues associated with SNAPIN recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >6 publications with SNAPIN and Disease Models, Animal
 Death Antibodies  >3 publications with SNAPIN and Death
 Hypertrophy Antibodies  >2 publications with SNAPIN and Hypertrophy
 Learning Disorders Antibodies  >1 publications with SNAPIN and Learning Disorders
 Hyperglycemia Antibodies  >1 publications with SNAPIN and Hyperglycemia
 Heart Diseases Antibodies  >1 publications with SNAPIN and Heart Diseases
 Cognition Disorders Antibodies  >1 publications with SNAPIN and Cognition Disorders
 Carcinoma, Hepatocellular Antibodies  >1 publications with SNAPIN and Carcinoma, Hepatocellular
 Inflammation Antibodies  >1 publications with SNAPIN and Inflammation
 Liver Neoplasms Antibodies  >1 publications with SNAPIN and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with SNAPIN and Brain
 Kidney Antibodies  >7 publications with SNAPIN and Kidney
 Pancreas Antibodies  >6 publications with SNAPIN and Pancreas
 Muscle Antibodies  >4 publications with SNAPIN and Muscle
 Blood Antibodies  >4 publications with SNAPIN and Blood
 Liver Antibodies  >3 publications with SNAPIN and Liver
 Heart Antibodies  >3 publications with SNAPIN and Heart
 Uncharacterized Tissue Antibodies  >2 publications with SNAPIN and Uncharacterized Tissue
 Prostate Antibodies  >2 publications with SNAPIN and Prostate
 Testis Antibodies  >1 publications with SNAPIN and Testis
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