NP_009172
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31.4kDa (282aa) confirmed by MALDI-TOF
NCBI Official Full Name
vacuolar-sorting protein SNF8 isoform 1
NCBI Official Synonym Full Names
SNF8, ESCRT-II complex subunit
NCBI Protein Information
vacuolar-sorting protein SNF8
UniProt Protein Name
Vacuolar-sorting protein SNF8
UniProt Synonym Protein Names
ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22
UniProt Synonym Gene Names
NCBI Summary for SNF8
The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Comments for SNF8
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Product References and Citations for SNF8 recombinant protein
Maleroed L., et al. (2007) Traffic 8:1617-1629; Raiborg C., et al. (2008) Exp. Cell Res. 314:801-813
Research Articles on SNF8
Precautions
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Products associated with SNF8 recombinant protein
Pathways associated with SNF8 recombinant protein
Diseases associated with SNF8 recombinant protein
Organs/Tissues associated with SNF8 recombinant protein
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