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SORD recombinant protein

Scan QR to view Datasheet Catalog #    MBS203476
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Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SORD, Recombinant Protein

 Also Known As   

SORD, 1-357aa, Human, His tag, E Coli (Bioactivity Validated)

 Product Synonym Names    Sorbitol dehydrogenase; Sorbitol dehydrogenase L iditol 2 dehydrogenase; SDH; SORD; SORD 1; SORD1
 Product Gene Name   

SORD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVKHLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIKGVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP
 OMIM    U07361 mRNA
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Biological Activity    Specific activity is > 20,000 pmol/min/ug, and is defined as the amount of enzyme that catalyze D-fructose to D-sorbitol per minute at pH 7.5 at 37C.
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SORD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SORD recombinant protein

   SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family. It is widely expressed with highest expression in kidney and in the lens of the eye. SORD enzymatically catalyzes the zinc-dependent interconversion of polyols, such as sorbitol and xylitol, to their respective ketoses. Recombinant human SORD protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for SORD recombinant protein    Metabolism
 Applications Tested/Suitable for SORD recombinant protein   

SDS-PAGE

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 SDS-Page of SORD recombinant protein    SORD recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for SORD. It may not necessarily be applicable to this product.
 NCBI GI #    19263809
 NCBI GeneID    6652
 NCBI Accession #    AAH25295 [Other Products]
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 UniProt Secondary Accession #    Q16682; Q9UMD6; B2R655; B7Z3A6; J3JZZ5 [Other Products]
 UniProt Related Accession #    Q00796 [Other Products]
 Molecular Weight    40.4 kDa (377aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    Sorbitol dehydrogenase
 NCBI Official Synonym Full Names    sorbitol dehydrogenase
 NCBI Official Symbol    SORD [Similar Products]
 NCBI Official Synonym Symbols   
SORD1; HEL-S-95n
[Similar Products]
 NCBI Protein Information    sorbitol dehydrogenase
 UniProt Protein Name    Sorbitol dehydrogenase
 UniProt Synonym Protein Names   
L-iditol 2-dehydrogenase
 Protein Family    Sorbitol-6-phosphate 2-dehydrogenase
 UniProt Gene Name    SORD [Similar Products]
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 NCBI Summary for SORD    Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]
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 UniProt Comments for SORD    Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.
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Product References and Citations for SORD recombinant protein

   Baker MA., et al. (2010) Proteomics. 10 (3):482-95. ; Sorger D., et al. (2009) Nucl Med Biol. 36 (1):17-27.;
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 Research Articles on SORD    1. SDH gene expression was increased by hypoxia and oxidative stress, but not extracellular hyperosmolarity. Hyperosmolarity and hypoxia did not alter the SDH protein level.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SORD recombinant proteinPathways associated with SORD recombinant protein
 Reference Product  PubMed Publications
 AKR1B1 recombinant protein  >3 publications with SORD and AKR1B1
 HK1 recombinant protein  >2 publications with SORD and HK1
 CAT recombinant protein  >1 publications with SORD and CAT
 KHK recombinant protein  >1 publications with SORD and KHK
 Products by Pathway  Pathway Diagram
 Catabolism Of Glucuronate To Xylulose-5-phosphate Pathway antibodies  Catabolism Of Glucuronate To Xylulose-5-phosphate Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose Biosynthesis Pathway antibodies  Fructose Biosynthesis Pathway Diagram
 Fructose Metabolism Pathway antibodies  Fructose Metabolism Pathway Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Glucuronate Pathway (uronate Pathway) antibodies  Glucuronate Pathway (uronate Pathway) Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
Diseases associated with SORD recombinant proteinOrgans/Tissues associated with SORD recombinant protein
 Disease Name  Pubmed Publications
 Infertility, Male Antibodies  >2 publications with SORD and Infertility, Male
 Liver Diseases Antibodies  >2 publications with SORD and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with SORD and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >1 publications with SORD and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with SORD and Lung Neoplasms
 Hyperglycemia Antibodies  >1 publications with SORD and Hyperglycemia
 Liver Neoplasms Antibodies  >1 publications with SORD and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with SORD and Kidney Diseases
 Inflammation Antibodies  >1 publications with SORD and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with SORD and Blood
 Brain Antibodies  >8 publications with SORD and Brain
 Eye Antibodies  >4 publications with SORD and Eye
 Liver Antibodies  >4 publications with SORD and Liver
 Lung Antibodies  >3 publications with SORD and Lung
 Kidney Antibodies  >3 publications with SORD and Kidney
 Vascular Antibodies  >3 publications with SORD and Vascular
 Testis Antibodies  >2 publications with SORD and Testis
 Muscle Antibodies  >2 publications with SORD and Muscle
 Uterus Antibodies  >1 publications with SORD and Uterus
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