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SOSTDC1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204804
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOSTDC1, Recombinant Protein

★Popular Item★
 Also Known As   

SOSTDC1, 24-206aa, Human, His tag, E Coli (Denatured)

 Product Synonym Names    Sclerostin domain-containing protein 1; CDA019; ECTODIN; uSAG1
 Product Gene Name   

SOSTDC1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSFKNDATE ILYSHVVKPV PAHPSSNSTL NQARNGGRHF SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE SMSPAKPVQH HRERKRASKS SKHSMS
 OMIM    AB059270 mRNA
 3D Structure    ModBase 3D Structure for Q6X4U4
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 Host    E Coli
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 Purity/Purification    > 85% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SOSTDC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SOSTDC1 recombinant protein

   SOSTDC1 is a member of the sclerostin family and an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. Recombinant human SOSTDC1 protein, fused to His-tag at N-terminus, was expressed in E Coli.
 Product Categories/Family for SOSTDC1 recombinant protein    Signal Transduction
 Applications Tested/Suitable for SOSTDC1 recombinant protein   

SDS-PAGE

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 SDS-Page of SOSTDC1 recombinant protein    SOSTDC1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for SOSTDC1. It may not necessarily be applicable to this product.
 NCBI GI #    23943785
 NCBI GeneID    25928
 NCBI Accession #    NP_056279 [Other Products]
 NCBI GenBank Nucleotide #    NM_015464.2 [Other Products]
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 UniProt Primary Accession #    Q6X4U4 [Other Products]
 UniProt Secondary Accession #    Q96HJ7; Q9Y3U3; A8MUA6 [Other Products]
 UniProt Related Accession #    Q6X4U4 [Other Products]
 Molecular Weight    23kDa (206aa)
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 NCBI Official Full Name    sclerostin domain-containing protein 1
 NCBI Official Synonym Full Names    sclerostin domain containing 1
 NCBI Official Symbol    SOSTDC1 [Similar Products]
 NCBI Official Synonym Symbols   
DAND7; USAG1; CDA019; ECTODIN
[Similar Products]
 NCBI Protein Information    sclerostin domain-containing protein 1
 UniProt Protein Name    Sclerostin domain-containing protein 1
 UniProt Synonym Protein Names   
Ectodermal BMP inhibitor; Ectodin; Uterine sensitization-associated gene 1 protein; USAG-1
 Protein Family    Sclerostin domain-containing protein
 UniProt Gene Name    SOSTDC1 [Similar Products]
 UniProt Synonym Gene Names    USAG1; Ectodin; USAG-1 [Similar Products]
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 NCBI Summary for SOSTDC1    This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOSTDC1    May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
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Product References and Citations for SOSTDC1 recombinant protein

   Yanagita M, Oka M, et al. (2004). Biochem Biophys Res Commun. 316 (2):490-500.; Goto M, et al. (2004). J Biol Chem. 279 (40):42128-38.
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 Research Articles on SOSTDC1    1. Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SOSTDC1 recombinant proteinPathways associated with SOSTDC1 recombinant protein
 Reference Product  PubMed Publications
 BMP4 recombinant protein  >8 publications with SOSTDC1 and BMP4
 BMP7 recombinant protein  >5 publications with SOSTDC1 and BMP7
 BMP2 recombinant protein  >2 publications with SOSTDC1 and BMP2
 CER1 recombinant protein  >1 publications with SOSTDC1 and CER1
 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
Diseases associated with SOSTDC1 recombinant proteinOrgans/Tissues associated with SOSTDC1 recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >13 publications with SOSTDC1 and Kidney Diseases
 Congenital Abnormalities Antibodies  >13 publications with SOSTDC1 and Congenital Abnormalities
 Inflammation Antibodies  >5 publications with SOSTDC1 and Inflammation
 Fibrosis Antibodies  >3 publications with SOSTDC1 and Fibrosis
 Musculoskeletal Abnormalities Antibodies  >3 publications with SOSTDC1 and Musculoskeletal Abnormalities
 Breast Neoplasms Antibodies  >2 publications with SOSTDC1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >2 publications with SOSTDC1 and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with SOSTDC1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >2 publications with SOSTDC1 and Nervous System Diseases
 Abnormalities, Multiple Antibodies  >2 publications with SOSTDC1 and Abnormalities, Multiple
 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >23 publications with SOSTDC1 and Mouth
 Embryonic Tissue Antibodies  >21 publications with SOSTDC1 and Embryonic Tissue
 Kidney Antibodies  >18 publications with SOSTDC1 and Kidney
 Skin Antibodies  >9 publications with SOSTDC1 and Skin
 Connective Tissue Antibodies  >7 publications with SOSTDC1 and Connective Tissue
 Brain Antibodies  >6 publications with SOSTDC1 and Brain
 Uterus Antibodies  >3 publications with SOSTDC1 and Uterus
 Vascular Antibodies  >3 publications with SOSTDC1 and Vascular
 Lung Antibodies  >2 publications with SOSTDC1 and Lung
 Intestine Antibodies  >2 publications with SOSTDC1 and Intestine
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