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SOX9 recombinant protein

Scan QR to view Datasheet Catalog #    MBS143706 SOX9 recombinant protein
Unit / Price
0.002 mg  /  $290 +1 FREE 8GB USB
0.005 mg  /  $480 +1 FREE 8GB USB
0.01 mg  /  $790 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOX9, Recombinant Protein

 Also Known As   

Recombinant Human SOX9

 Product Synonym Names    SOX9 Human; SOX9 Human Recombinant; SOX-9; SRY (sex determining region Y)-box 9 (campomelic dysplasia; autosomal sex-reversal); Transcription factor SOX-9; SOX9; CMD1; SRA1; CMPD1
 Product Gene Name   

SOX9 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114290
 3D Structure    ModBase 3D Structure for P48436
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 Host    E Coli
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 Form/Format    SOX9 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
 Other Notes    Small volumes of SOX9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SOX9 recombinant protein

   Description: SOX9 Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 150 amino acids (1-150 a.a.) fused to a GST tag and having a total molecular mass of 43kDa. The SOX9 is purified by proprietary chromatographic techniques.

Introduction: SOX9 is involved in skeletal development. SOX9 regulates the expression of other genes which play a role in chondrogenesis by performing as a transcription factor for these genes. SOX9 takes part in chondrocyte differentiation and, together with steroidogenic factor 1; SOX9 regulates transcription of the anti-Muellerian hormone gene. Deficiencies of SOX9 result in skeletal malformation syndrome campomelic dysplasia, often with sex reversal. SOX9 is a transcription factor having vast mobility group DNA-binding domain that is expressed in all prechondrocytic and chondrocytic cells throughout embryonic growth. SOX9 Phosphorylation by PKA raises its DNA binding and transcriptional activity. SOX9 controls expression of chondrocyte phenotype related genes. IL-1 and TNF-a decrease SOX9 levels of mRNA and/or protein in chondrocytes, therefore strongly inhibit the expression of genes for cartilage extracellular matrix proteins. SOX9 down-regulation takes part in inhibiting expression of the cartilage phenotype in inflammatory joint diseases.
 Product Categories/Family for SOX9 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; SRY (Sex Determining Region Y)-Box
NCBI/Uniprot data below describe general gene information for SOX9. It may not necessarily be applicable to this product.
 NCBI GI #    4557853
 NCBI GeneID    6662
 NCBI Accession #    NP_000337.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000346.3 [Other Products]
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 UniProt Primary Accession #    P48436 [Other Products]
 UniProt Secondary Accession #    Q53Y80 [Other Products]
 UniProt Related Accession #    P48436 [Other Products]
 Molecular Weight    56,137 Da
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 NCBI Official Full Name    transcription factor SOX-9
 NCBI Official Synonym Full Names    SRY (sex determining region Y)-box 9
 NCBI Official Symbol    SOX9 [Similar Products]
 NCBI Official Synonym Symbols   
CMD1; SRA1; CMPD1
[Similar Products]
 NCBI Protein Information    transcription factor SOX-9; SRY (sex-determining region Y)-box 9 protein; SRY-related HMG-box, gene 9
 UniProt Protein Name    Transcription factor SOX-9
 Protein Family    Transcription factor
 UniProt Gene Name    SOX9 [Similar Products]
 UniProt Entry Name    SOX9_HUMAN
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 NCBI Summary for SOX9    The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOX9    SOX9: Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Defects in SOX9 are the cause of campomelic dysplasia (CMD1). CMD1 is a rare, often lethal, dominantly inherited, congenital osteochondrodysplasia, associated with male- to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognatia, flat face and hypertelorism are common. Various defects of the ear are often evident, affecting the cochlea, malleus incus, stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage. Defects in SOX9 are the cause of 46,XX sex reversal type 2 (SRXX2). SRXX2 is a condition in which male gonads develop in a genetic female (female to male sex reversal).

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: nucleoplasm; protein complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein heterodimerization activity; beta-catenin binding; bHLH transcription factor binding; chromatin binding; transcription factor activity; protein kinase activity

Biological Process: prostate gland development; extracellular matrix organization and biogenesis; somatic stem cell maintenance; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; negative regulation of epithelial cell differentiation; notochord development; protein amino acid phosphorylation; regulation of apoptosis; negative regulation of bone mineralization; cell-cell adhesion; hair follicle development; positive regulation of mesenchymal cell proliferation; tissue homeostasis; negative regulation of ossification; oligodendrocyte differentiation; positive regulation of epithelial cell differentiation; protein complex assembly; cartilage condensation; negative regulation of photoreceptor cell differentiation; positive regulation of phosphoinositide 3-kinase cascade; nucleosome assembly; positive regulation of chondrocyte differentiation; retina development in camera-type eye; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; transcription from RNA polymerase II promoter; neural crest cell development; Sertoli cell differentiation; cell fate specification; negative regulation of immune system process; signal transduction; cAMP-mediated signaling; mammary gland development; positive regulation of cell proliferation; protein kinase B signaling cascade; otic vesicle formation; skeletal development; negative regulation of epithelial cell proliferation; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; ossification; male gonad development; cytoskeleton organization and biogenesis; Sertoli cell development; endocrine pancreas development; male germ-line sex determination; regulation of cell proliferation; chromatin remodeling; limb bud formation; ureteric bud branching; cartilage development; epithelial to mesenchymal transition; spermatogenesis; positive regulation of protein amino acid phosphorylation; negative regulation of myoblast differentiation

Disease: Campomelic Dysplasia; 46,xy Sex Reversal 10
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 Research Articles on SOX9    1. SOX9 is a transcription factor that regulates bile duct development and contributes to liver regeneration and fibrosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SOX9 recombinant proteinPathways associated with SOX9 recombinant protein
 Reference Product  PubMed Publications
 COL2A1 recombinant protein  >283 publications with SOX9 and COL2A1
 RUNX2 recombinant protein  >248 publications with SOX9 and RUNX2
 WT1 recombinant protein  >97 publications with SOX9 and WT1
 ACAN recombinant protein  >68 publications with SOX9 and ACAN
 COL10A1 recombinant protein  >67 publications with SOX9 and COL10A1
 BMP4 recombinant protein  >53 publications with SOX9 and BMP4
 SHH recombinant protein  >46 publications with SOX9 and SHH
 COL11A2 recombinant protein  >18 publications with SOX9 and COL11A2
 MED12 recombinant protein  >6 publications with SOX9 and MED12
 EP300 recombinant protein  >4 publications with SOX9 and EP300
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
Diseases associated with SOX9 recombinant proteinOrgans/Tissues associated with SOX9 recombinant protein
 Disease Name  Pubmed Publications
 Campomelic Dysplasia Antibodies  >129 publications with SOX9 and Campomelic Dysplasia
 Hypertrophy Antibodies  >103 publications with SOX9 and Hypertrophy
 Carcinoma Antibodies  >100 publications with SOX9 and Carcinoma
 Disease Models, Animal Antibodies  >85 publications with SOX9 and Disease Models, Animal
 Nervous System Diseases Antibodies  >61 publications with SOX9 and Nervous System Diseases
 Adenocarcinoma Antibodies  >55 publications with SOX9 and Adenocarcinoma
 Inflammation Antibodies  >48 publications with SOX9 and Inflammation
 Craniofacial Abnormalities Antibodies  >43 publications with SOX9 and Craniofacial Abnormalities
 Necrosis Antibodies  >34 publications with SOX9 and Necrosis
 Fibrosis Antibodies  >32 publications with SOX9 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >885 publications with SOX9 and Bone
 Testis Antibodies  >458 publications with SOX9 and Testis
 Connective Tissue Antibodies  >443 publications with SOX9 and Connective Tissue
 Embryonic Tissue Antibodies  >363 publications with SOX9 and Embryonic Tissue
 Muscle Antibodies  >120 publications with SOX9 and Muscle
 Brain Antibodies  >102 publications with SOX9 and Brain
 Liver Antibodies  >90 publications with SOX9 and Liver
 Nerve Antibodies  >84 publications with SOX9 and Nerve
 Pancreas Antibodies  >83 publications with SOX9 and Pancreas
 Skin Antibodies  >80 publications with SOX9 and Skin
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