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KITLG recombinant protein :: STEM CELL FACTOR Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS232270 KITLG recombinant protein
Unit / Price
0.01 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STEM CELL FACTOR (KITLG), Recombinant Protein

 Also Known As   

RECOMBINANT HUMAN STEM CELL FACTOR

 Product Gene Name   

KITLG recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    145250
 3D Structure    ModBase 3D Structure for P21583
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 Purity/Purification    >98% by SDS PAGE and HPLC analysis
 Form/Format    Purified recombinant protein expressed in E Coli - lyophilised
 Concentration    Total protein concentration 0.1mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.1ml distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
 Buffer Solution    10mM Acetic acid
 Activity    5 x 105 U/mg as determined by dose-dependent stimulation of proliferation on human TF-1 cells.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution
 Other Notes    Small volumes of KITLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for KITLG recombinant protein

   Stem cell factor (SCF) is a haematopoietic growth factor acting during early stages of haemopoiesis. SCF stimulates proliferation of myeloid, erythroid and lymphoid progenitors in bone marrow cultures and appears to act synergistically with the colony stimulating factors.
 Applications Tested/Suitable for KITLG recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for KITLG recombinant protein    ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well;
Functional Assays: Minimum Dilution: 0.2; Maximum Dilution: 20.0ng/ml;
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane
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NCBI/Uniprot data below describe general gene information for KITLG. It may not necessarily be applicable to this product.
 NCBI GI #    4505175
 NCBI GeneID    4254
 NCBI Accession #    NP_000890.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000899.4 [Other Products]
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 UniProt Primary Accession #    P21583 [Other Products]
 UniProt Secondary Accession #    Q16487; Q68DZ2; Q7M4N8; Q9UQK7; A0AV09; A8K2Q4; B7ZLM4 [Other Products]
 UniProt Related Accession #    P21583 [Other Products]
 Molecular Weight    Protein Molecular Weight: 18.4kD (165 Amino acid sequence) [Similar Products]
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 NCBI Official Full Name    kit ligand isoform b
 NCBI Official Synonym Full Names    KIT ligand
 NCBI Official Symbol    KITLG [Similar Products]
 NCBI Official Synonym Symbols   
SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7
[Similar Products]
 NCBI Protein Information    kit ligand; c-Kit ligand; familial progressive hyperpigmentation 2; mast cell growth factor; steel factor; stem cell factor
 UniProt Protein Name    Kit ligand
 UniProt Synonym Protein Names   
Mast cell growth factor; MGF; Stem cell factor; SCF; c-Kit ligandSoluble KIT ligand; sKITLG
 Protein Family    Kit ligand
 UniProt Gene Name    KITLG [Similar Products]
 UniProt Synonym Gene Names    MGF; SCF; MGF; SCF; sKITLG [Similar Products]
 UniProt Entry Name    SCF_HUMAN
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 NCBI Summary for KITLG    This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KITLG    SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: extracellular space; cytoskeleton; cytoplasm; extracellular region; integral to membrane; plasma membrane

Molecular Function: protein binding; growth factor activity; cytokine activity; stem cell factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; embryonic hemopoiesis; germ cell programmed cell death; male gonad development; signal transduction; positive regulation of MAP kinase activity; cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of melanocyte differentiation; negative regulation of mast cell apoptosis; innate immune response; positive regulation of myeloid leukocyte differentiation; positive regulation of Ras protein signal transduction; cell adhesion; neural crest cell migration; positive regulation of DNA replication

Disease: Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7
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 Research Articles on KITLG    1. These findings suggest that integration of SCF and LTD4 signals may contribute to MC hyperplasia and hyper-reactivity during airway hyper-response and inflammation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to RECOMBINANT HUMAN STEM CELL FACTOR
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 MBS008088  Rat Stem Cell Factor Receptor ELISA Kit  MBS100830  Donkey Stem Cell Factor Receptor ELISA Kit
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Products associated with KITLG recombinant proteinPathways associated with KITLG recombinant protein
 Reference Product  PubMed Publications
 KIT recombinant protein  >3766 publications with KITLG and KIT
 STAT3 recombinant protein  >924 publications with KITLG and STAT3
 JAK2 recombinant protein  >282 publications with KITLG and JAK2
 EPOR recombinant protein  >110 publications with KITLG and EPOR
 GRB2 recombinant protein  >86 publications with KITLG and GRB2
 LYN recombinant protein  >54 publications with KITLG and LYN
 CSF2 recombinant protein  >6 publications with KITLG and CSF2
 FER recombinant protein  >6 publications with KITLG and FER
 MATK recombinant protein  >3 publications with KITLG and MATK
 CMA1 recombinant protein  >1 publications with KITLG and CMA1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
Diseases associated with KITLG recombinant proteinOrgans/Tissues associated with KITLG recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3650 publications with KITLG and Necrosis
 Bone Marrow Diseases Antibodies  >3193 publications with KITLG and Bone Marrow Diseases
 Carcinoma Antibodies  >2514 publications with KITLG and Carcinoma
 Inflammation Antibodies  >2070 publications with KITLG and Inflammation
 Neoplasms, Germ Cell and Embryonal Antibodies  >1789 publications with KITLG and Neoplasms, Germ Cell and Embryonal
 Heart Diseases Antibodies  >1487 publications with KITLG and Heart Diseases
 Breast Neoplasms Antibodies  >1380 publications with KITLG and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1305 publications with KITLG and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >1113 publications with KITLG and Lung Diseases
 Myocardial Ischemia Antibodies  >1099 publications with KITLG and Myocardial Ischemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18932 publications with KITLG and Blood
 Bone Antibodies  >17502 publications with KITLG and Bone
 Vascular Antibodies  >6473 publications with KITLG and Vascular
 Brain Antibodies  >5753 publications with KITLG and Brain
 Embryonic Tissue Antibodies  >5233 publications with KITLG and Embryonic Tissue
 Muscle Antibodies  >3845 publications with KITLG and Muscle
 Nerve Antibodies  >3547 publications with KITLG and Nerve
 Liver Antibodies  >2678 publications with KITLG and Liver
 Connective Tissue Antibodies  >2130 publications with KITLG and Connective Tissue
 Lung Antibodies  >1915 publications with KITLG and Lung
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